Coincidence of Candida Endophthalmitis, and Aspergillus and Pneumocystis jirovecii Pneumonia in a COVID-19 Patient: Case Report

被引:3
作者
Tehrani, Shabnam [1 ]
Fekri, Sahba [2 ]
Demirci, Hakan [3 ]
Nourizadeh, Amir Mohammad [4 ]
Kashefizadeh, Alireza [5 ]
Shahrbaf, Mohammad Amin [4 ]
Keyvanfar, Amirreza [6 ]
Nejad, Fatemeh Maghsoudi [1 ]
机构
[1] Shahid Beheshti Univ Med Sci, Labbafinejad Clin Res Ctr, Dept Infect Dis, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Labbafinejad Clin Res Ctr, Dept Ophthalmol, Tehran, Iran
[3] Univ Michigan, Dept Ophthalmol & Visual Sci, Ann Arbor, MI USA
[4] Shahid Beheshti Univ Med Sci, Fac Med, Tehran, Iran
[5] Shahid Beheshti Univ Med Sci, Labbafinejad Clin Res Ctr, Dept Internal Med, Tehran, Iran
[6] Shahid Beheshti Univ Med Sci, Infect Dis & Trop Med Res Ctr, Tehran, Iran
关键词
Aspergillosis; candidiasis; COVID-19; endophthalmitis; Pneumocystis pneumonia; FUNGAL-INFECTIONS; DIAGNOSIS;
D O I
10.1080/09273948.2023.2188224
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Introduction: Coronavirus disease 2019 (COVID-19) is associated with immune system dysfunction and makes patients vulnerable to opportunistic infections. This report presents a patient with a history of COVID-19, suffering from opportunistic infections. Case description: We reported a 64-year-old man complaining of progressive visual loss in his left eye, who had previously been hospitalized for three weeks due to COVID-19. In the ophthalmologic assessment, large foci of dense subretinal and intraretinal infiltrations involving the macula were observed (compatible with endogenous fungal endophthalmitis). Real-time PCR result of intraocular fluid was positive for Candida spp. During subsequent hospitalization, the patient also suffered from fever and productive coughs (manifestations of pneumonia caused by Aspergillus fumigatus and Pneumocystis jirovecii). In response to antibiotic therapy, the fever and coughs subsided, and the ocular examination revealed a dramatic decrease in the size of retinal infiltrations. Conclusions: In patients with severe COVID-19, long-term ICU admission and immunosuppressive drugs lead to immune system dysfunction and make the patient more susceptible to opportunistic infections. Consequently, fungal pathogens such as Aspergillus, Pneumocystis jirovecii, and Candida spp. may cause infection in different body organs. Thus, clinicians should be alert and have clinical suspicion to diagnose accurately and manage patients accordingly.
引用
收藏
页码:1291 / 1294
页数:4
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