Orphan peptide and G protein-coupled receptor signalling in alcohol use disorder

被引：1

作者：

Anversa, Roberta Goncalves ^{[1
,2
]}

Maddern, Xavier J. ^{[1
,2
]}

Lawrence, Andrew J. ^{[1
,2
]}

Walker, Leigh C. ^{[1
,2
,3
]}

机构：

[1] Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia

[2] Univ Melbourne, Florey Dept Neurosci & Mental Hlth, Melbourne, Vic, Australia

[3] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne Brain Ctr, 30 Royal Parade, Melbourne, Vic 3052, Australia

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2024年 / 181卷 / 05期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

alcohol use disorder; CART; GPCR; GPR135; GPR158; GPR26; GPR6; GPR88; neuropeptide; orphan; AMPHETAMINE-REGULATED TRANSCRIPT; CONTEXT-INDUCED REINSTATEMENT; CONCISE GUIDE; MOLECULAR-CLONING; COCAINE; CART; EXPRESSION; GPR139; GENE; IDENTIFICATION;

D O I：

10.1111/bph.16301

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Neuropeptides and G protein-coupled receptors (GPCRs) have long been, and continue to be, one of the most popular target classes for drug discovery in CNS disorders, including alcohol use disorder (AUD). Yet, orphaned neuropeptide systems and receptors (oGPCR), which have no known cognate receptor or ligand, remain understudied in drug discovery and development. Orphan neuropeptides and oGPCRs are abundantly expressed within the brain and represent an unprecedented opportunity to address brain function and may hold potential as novel treatments for disease. Here, we describe the current literature regarding orphaned neuropeptides and oGPCRs implicated in AUD. Specifically, in this review, we focus on the orphaned neuropeptide cocaine- and amphetamine-regulated transcript (CART), and several oGPCRs that have been directly implicated in AUD (GPR6, GPR26, GPR88, GPR139, GPR158) and discuss their potential and pitfalls as novel treatments, and progress in identifying their cognate receptors or ligands.

引用

页码：595 / 609

页数：15

共 134 条

[1] THE FUNCTIONAL-ANATOMY OF BASAL GANGLIA DISORDERS [J].

ALBIN, RL ;

YOUNG, AB ;

PENNEY, JB .

TRENDS IN NEUROSCIENCES, 1989, 12 (10) :366-375

[2] THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors [J].

Alexander, Stephen P. H. ;

Christopoulos, Arthur ;

Davenport, Anthony P. ;

Kelly, Eamonn ;

Mathie, Alistair ;

Peters, John A. ;

Veale, Emma L. ;

Armstrong, Jane F. ;

Faccenda, Elena ;

Harding, Simon D. ;

Pawson, Adam J. ;

Southan, Christopher ;

Davies, Jamie A. ;

Abbracchio, Maria Pia ;

Alexander, Wayne ;

Al-hosaini, Khaled ;

Baeck, Magnus ;

Barnes, Nicholas M. ;

Bathgate, Ross ;

Beaulieu, Jean-Martin ;

Bernstein, Kenneth E. ;

Bettler, Bernhard ;

Birdsall, Nigel J. M. ;

Blaho, Victoria ;

Boulay, Francois ;

Bousquet, Corinne ;

Braeuner-Osborne, Hans ;

Burnstock, Geoffrey ;

Calo, Girolamo ;

Castano, Justo P. ;

Catt, KevinJ ;

Ceruti, Stefania ;

Chazot, Paul ;

Chiang, Nan ;

Chini, Bice ;

Chun, Jerold ;

Cianciulli, Antonia ;

Civelli, Olivier ;

Clapp, Lucie H. ;

Couture, Rejean ;

Csaba, Zsolt ;

Dahlgren, Claes ;

Dent, Gordon ;

Singh, Khuraijam Dhanachandra ;

Douglas, Steven D. ;

Dournaud, Pascal ;

Eguchi, Satoru ;

Escher, Emanuel ;

Filardo, Edward J. ;

Fong, Tung .

BRITISH JOURNAL OF PHARMACOLOGY, 2021, 178 :S27-S156

[3] THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters [J].

Alexander, Stephen P. H. ;

Kelly, Eamonn ;

Mathie, Alistair ;

Peters, John A. ;

Veale, Emma L. ;

Armstrong, Jane F. ;

Faccenda, Elena ;

Harding, Simon D. ;

Pawson, Adam J. ;

Southan, Christopher ;

Davies, Jamie A. ;

Amarosi, Laura ;

Anderson, Catriona M. H. ;

Beart, Philip Mark ;

Broer, Stefan ;

Dawson, Paul A. ;

Hagenbuch, Bruno ;

Hammond, James R. ;

Inui, Ken-ichi ;

Kanai, Yoshikatsu ;

Kemp, Stephan ;

Stewart, Gavin ;

Thwaites, David T. ;

Verri, Tiziano .

BRITISH JOURNAL OF PHARMACOLOGY, 2021, 178 :S412-S513

[4] THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets [J].

Alexander, Stephen P. H. ;

Kelly, Eamonn ;

Mathie, Alistair ;

Peters, John A. ;

Veale, Emma L. ;

Armstrong, Jane F. ;

Faccenda, Elena ;

Harding, Simon D. ;

Pawson, Adam J. ;

Sharman, Joanna L. ;

Southan, Christopher ;

Buneman, O. Peter ;

Cidlowski, John A. ;

Christopoulos, Arthur ;

Davenport, Anthony P. ;

Fabbro, Doriano ;

Spedding, Michael ;

Striessnig, Jorg ;

Davies, Jamie A. ;

Ahlers-Dannen, Katelin E. ;

Alqinyah, Mohammed ;

Arumugam, Thiruma, V ;

Bodle, Christopher ;

Dagner, Josephine Buo ;

Chakravarti, Bandana ;

Choudhuri, Shreoshi P. ;

Druey, Kirk M. ;

Fisher, Rory A. ;

Gerber, Kyle J. ;

Hepler, John R. ;

Hooks, Shelley B. ;

Kantheti, Havish S. ;

Karaj, Behirda ;

Layeghi-Ghalehsoukhteh, Somayeh ;

Lee, Jae-Kyung ;

Luo, Zili ;

Martemyanov, Kirill ;

Mascarenhas, Luke D. ;

McNabb, Harrison ;

Montanez-Miranda, Carolina ;

Ogujiofor, Osita ;

Phan, Hoa ;

Roman, David L. ;

Shaw, Vincent ;

Sjogren, Benita ;

Sobey, Christopher ;

Spicer, Mackenzie M. ;

Squires, Katherine E. ;

Sutton, Laurie ;

Wendimu, Menbere .

BRITISH JOURNAL OF PHARMACOLOGY, 2021, 178 :S1-S26

[5] THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes [J].

Alexander, Stephen P. H. ;

Fabbro, Doriano ;

Kelly, Eamonn ;

Mathie, Alistair ;

Peters, John A. ;

Veale, Emma L. ;

Armstrong, Jane F. ;

Faccenda, Elena ;

Harding, Simon D. ;

Pawson, Adam J. ;

Southan, Christopher ;

Davies, Jamie A. ;

Boison, Detlev ;

Burns, Kathryn Elisa ;

Dessauer, Carmen ;

Gertsch, Jurg ;

Helsby, Nuala Ann ;

Izzo, Angelo A. ;

Koesling, Doris ;

Ostrom, Rennolds ;

Pyne, Nigel J. ;

Pyne, Susan ;

Russwurm, Michael ;

Seifert, Roland ;

Stasch, Johannes-Peter ;

van der Stelt, Mario ;

van der Vliet, Albert ;

Watts, Val ;

Wong, Szu Shen .

BRITISH JOURNAL OF PHARMACOLOGY, 2021, 178 :S313-S411

[6] THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors [J].

Alexander, Stephen P. H. ;

Christopoulos, Arthur ;

Davenport, Anthony P. ;

Kelly, Eamonn ;

Mathie, Alistair ;

Peters, John A. ;

Veale, Emma L. ;

Armstrong, Jane F. ;

Faccenda, Elena ;

Harding, Simon D. ;

Pawson, Adam J. ;

Sharman, Joanna L. ;

Southan, Christopher ;

Davies, Jamie A. ;

Arumugam, Thiruma V. ;

Bennett, Andrew ;

Sjogren, Benita ;

Sobey, Christopher ;

Wong, Szu Shen ;

Abbracchio, Maria P. ;

Alexander, Wayne ;

Al-hosaini, Khaled ;

Back, Magnus ;

Beaulieu, Jean-Martin ;

Bernstein, Kenneth E. ;

Bettler, Bernhard ;

Birdsall, Nigel J. M. ;

Blaho, Victoria ;

Bousquet, Corinne ;

Brauner-Osborne, Hans ;

Burnstock, Geoffrey ;

Calo, Girolamo ;

Castano, Justo P. ;

Catt, Kevin J. ;

Ceruti, Stefania ;

Chazot, Paul ;

Chiang, Nan ;

Chun, Jerold ;

Cianciulli, Antonia ;

Clapp, Lucie H. ;

Couture, Rejean ;

Csaba, Zsolt ;

Dent, Gordon ;

Singh, Khuraijam Dhanachandra ;

Douglas, Steven D. ;

Dournaud, Pascal ;

Eguchi, Satoru ;

Escher, Emanuel ;

Filardo, Edward ;

Fong, Tung M. .

BRITISH JOURNAL OF PHARMACOLOGY, 2019, 176 :S21-S141

[7] THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors [J].

Alexander, Stephen P. H. ;

Christopoulos, Arthur ;

Davenport, Anthony P. ;

Kelly, Eamonn ;

Marrion, Neil V. ;

Peters, John A. ;

Faccenda, Elena ;

Harding, Simon D. ;

Pawson, Adam J. ;

Sharman, Joanna L. ;

Southan, Christopher ;

Davies, Jamie A. .

BRITISH JOURNAL OF PHARMACOLOGY, 2017, 174 :S17-S129

[8] Deleterious mutation in GPR88 is associated with chorea, speech delay, and learning disabilities [J].

Alkufri, Fadi ;

Shaag, Avraham ;

Abu-Libdeh, Bassam ;

Elpeleg, Orly .

NEUROLOGY-GENETICS, 2016, 2 (03)

[9] Naltrexone for the management of alcohol dependence [J].

Anton, Raymond F. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (07) :715-721

[10] The role of the habenula in the transition from reward to misery in substance use and mood disorders [J].

Batalla, Albert ;

Homberg, Judith R. ;

Lipina, Tatiana V. ;

Sescousse, Guillaume ;

Luijten, Maartje ;

Ivanova, Svetlana A. ;

Schellekens, Arnt F. A. ;

Loonen, Anton J. M. .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2017, 80 :276-285

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