The Crucial Role of the Interstitial Cells of Cajal in Neurointestinal Diseases

被引：8
作者：
Choi, Egan L. [1 ,2 ,3 ]
Taheri, Negar [1 ,2 ,3 ]
Tan, Elijah [1 ,2 ,3 ]
Matsumoto, Kenjiro [4 ]
Hayashi, Yujiro [1 ,2 ,3 ]
机构：
[1] Mayo Clin, Coll Med & Sci, Enter Neurosci Program, Guggenheim 10,200 1st St SW, Rochester, MN 55905 USA
[2] Mayo Clin, Coll Med & Sci, Dept Physiol & Biomed Engn, Guggenheim 10,200 1st St SW, Rochester, MN 55905 USA
[3] Mayo Clin, Coll Med & Sci, Gastroenterol Res Unit, Rochester, MN 55905 USA
[4] Doshisha Womens Coll Liberal Arts, Fac Pharmaceut Sci, Lab Pathophysiol, Kyoto 6100395, Japan
来源：
BIOMOLECULES | 2023年 / 13卷 / 09期
基金：
美国国家卫生研究院;
关键词：
interstitial cells of Cajal; neurointestinal diseases; gastrointestinal motility; IRRITABLE-BOWEL-SYNDROME; ENTERIC MOTOR-NEURONS; CLINICAL-PRACTICE GUIDELINE; ALPHA-DEFICIENT MICE; PHARMACOLOGICAL MANAGEMENT; HIRSCHSPRUNGS-DISEASE; OXIDATIVE STRESS; MUSCLE FUNCTION; NERVOUS-SYSTEM; MAST-CELLS;
D O I：
10.3390/biom13091358
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neurointestinal diseases result from dysregulated interactions between the nervous system and the gastrointestinal (GI) tract, leading to conditions such as Hirschsprung's disease and irritable bowel syndrome. These disorders affect many people, significantly diminishing their quality of life and overall health. Central to GI motility are the interstitial cells of Cajal (ICC), which play a key role in muscle contractions and neuromuscular transmission. This review highlights the role of ICC in neurointestinal diseases, revealing their association with various GI ailments. Understanding the functions of the ICC could lead to innovative perspectives on the modulation of GI motility and introduce new therapeutic paradigms. These insights have the potential to enhance efforts to combat neurointestinal diseases and may lead to interventions that could alleviate or even reverse these conditions.
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页数：18
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