The impact of vitamin D deficiency on clinical, biochemical and metabolic parameters in primary hyperparathyroidism

Background: It has been suggested that vitamin D deficiency is associated with worse clini-cal outcomes in primary hyperparathyroidism (PHPT). We aimed to evaluate the relationship between vitamin D deficiency and clinical, biochemical and metabolic parameters in PHPT patients. Methods: A total of 128 patients with biochemically confirmed PHPT were included. Patients were categorized as vitamin D deficient if 25-OH vitamin D was 50 nmol/L, or normal if vitamin D was 50 nmol/L. Biochemical parameters, bone mineral densitometry (BMD), and urinary tract and neck ultrasonography were assessed. Results: In the study group, 66 (51.6%) patients had vitamin D deficiency and 60 (48.4%) had normal vitamin D levels. Nephrolithiasis and osteoporosis were found in 26.6% and 30.5% of subjects, respectively. The prevalence of metabolic syndrome (MetS), obesity (BMI >30 kg/m2) and hypertension (HTN) were higher in the vitamin D deficient group when compared to the normal group (p = 0.04, p = 0.01 and p = 0.03, respectively). There was no difference regarding the presence of nephrolithiasis and osteoporosis between the groups. The mean adenoma size was similar in both groups. Conclusions: Vitamin D deficiency was not associated with osteoporosis, nephrolithiasis, ade-noma size or biochemical parameters in PHPT. However, vitamin D deficiency may be a risk factor for developing HTN and MetS in PHPT. (c) 2022 SEEN y SED. Published by Elsevier Espana, S.L.U. All rights reserved.