Crosstalk between cGAS-STING pathway and autophagy in cancer immunity

被引：17

作者：

Lu, Qijun ^{[1
]}

Chen, Yukun ^{[2
]}

Li, Jianwen ^{[1
]}

Zhu, Feng ^{[3
]}

Zheng, Zhan ^{[1
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Oncol, Shanghai, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Canc Inst, Shanghai, Peoples R China

[3] Fudan Univ, Huadong Hosp, Dept Lab Med, Shanghai, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

基金：

上海市自然科学基金;

关键词：

antitumor; autophagy; cancer; cGAS-STING; immunity; TUMOR MICROENVIRONMENT; CELL-DEATH; SELECTIVE AUTOPHAGY; INNATE IMMUNITY; STEM-CELLS; DNA; ACTIVATION; DEGRADATION; PROMOTES; PROTEIN;

D O I：

10.3389/fimmu.2023.1139595

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is critical in cancer immunity. Autophagy is a highly conserved process that is responsible for the degradation of cytoplasmic material and is involved in both innate and adaptive immunity. Recently, cGAS-STING and autophagy have been shown to be interconnected, which may influence the progression of cancer. Although cGAS-STING and autophagy have been shown to be interrelated in innate immunity, little has been reported about cancer immunity. As cancer immunity is key to treating tumors, it is essential to summarize the relationship and interactions between the two. Based on this, we systematically sorted out the recent findings of cGAS-STING and autophagy in cancer immunity and explored the interactions between cGAS-STING and autophagy, although these interactions have not been extensively studied. Lastly, we provide an outlook on how cGAS-STING and autophagy can be combined, with the hope that our research can help people better understand their potential roles in cancer immunity and bring light to the treatment of cancer.

引用

页数：14

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