Manganese-catalyzed Efficient Synthesis of N-heterocycles and Aminoketones Using Glycerol as a C3 Synthon

被引：2
作者：
Wei, Zeyuan [1 ]
Ke, Zhuofeng [2 ]
Wang, Yujie [1 ,3 ]
Liu, Qiang [1 ]
机构：
[1] Tsinghua Univ, Engn Res Ctr Adv Rare Earth Mat, Ctr Basic Mol Sci CBMS, Dept Chem,Minist Educ, Beijing 100084, Peoples R China
[2] Sun Yat Sen Univ, Sch Mat Sci & Engn, PCFM Lab, Guangzhou 510006, Peoples R China
[3] Henan Normal Univ, Pingyuan Lab, State Key Lab Antiviral Drugs, Xinxiang 453007, Henan, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2024年 / 30卷 / 14期
基金：
中国国家自然科学基金; 国家重点研发计划; 中国博士后科学基金;
关键词：
Dehydrogenation; Cross-coupling; Biomass; Manganese; Nitrogen heterocycles; SELECTIVE CONVERSION; LACTIC-ACID; OXIDATION; DERIVATIVES; BIOMASS; TRANSFORMATION; HYDROGENATION; CYCLOALKANES; QUINOXALINE; ALCOHOLS;
D O I：
10.1002/chem.202303481
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Glycerol is one of the important biomass-derived feedstocks and the high-value utilizations of glycerol have attracted much attentions in recent years. Herein, we report a manganese catalyzed dehydrogenative coupling of glycerol with amines for the synthesis of substituted 2-methylquinoxalines, 2-ethylbenzimidazoles, and alpha-aminoketones without any external oxidant. In these reactions, NHC-based pincer manganese complex featuring a pyridine backbone displayed high catalytic activity and selectivity, in which hydrogen and water were produced as the only by-products using glycerol as a C3 synthon.
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页数：5
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