Clinical course of hypertrophic cardiomyopathy patients implanted with a transvenous or subcutaneous defibrillator

被引:10
作者
Francia, Pietro [1 ]
Ziacchi, Matteo [2 ]
Adduci, Carmen [1 ]
Ammendola, Ernesto [3 ]
Pieragnoli, Paolo [4 ]
De Filippo, Paolo [5 ]
Rapacciuolo, Antonio [6 ]
Rella, Valeria [7 ]
Migliore, Federico [8 ]
Viani, Stefano [9 ]
Musumeci, Maria Beatrice [1 ]
Biagini, Elena [2 ]
Lovecchio, Mariolina [10 ]
Baldini, Rossella [1 ]
Falasconi, Giulio [11 ,12 ]
Autore, Camillo [1 ]
Biffi, Mauro [2 ]
Cecchi, Franco [4 ,7 ]
机构
[1] Univ Sapienza, St Andrea Hosp, Dept Clin & Mol Med, Cardiol, Rome, Italy
[2] Univ Bologna, Inst Cardiol, Dept Expt Diagnost & Specialty Med, Policlin S Orsola Malpighi, Bologna, Italy
[3] Univ Campania Luigi Vanvitelli, Monaldi Hosp, Dept Translat Med Sci, Naples, Italy
[4] Univ Florence, Careggi Univ Hosp, Florence, Italy
[5] Papa Giovanni XXIII Hosp, Bergamo, Italy
[6] Univ Naples Federico II, Dept Adv Biomed Sci, Naples, Italy
[7] San Luca Hosp, Ist Auxol Italiano, Dept Cardiovasc Neural & Metab Sci, IRCCS, Milan, Italy
[8] Univ Padua, Dept Cardiac Thorac Vasc Sci & Publ Hlth, Padua, Italy
[9] Univ Hosp Pisa, Cardiothorac & Vasc Dept, Cardiol Div 2, Pisa, Italy
[10] Boston Sci, Milan, Italy
[11] Univ Barcelona, Campus Clin, Barcelona, Spain
[12] IRCCS Humanitas Res Hosp, Milan, Italy
来源
EUROPACE | 2023年 / 25卷 / 09期
关键词
Hypertrophic cardiomyopathy; Implantable cardioverter-defibrillator; Subcutaneous implantable cardioverter-defibrillator; Device-related complications; SUDDEN CARDIAC DEATH; CARDIOVERTER-DEFIBRILLATOR; TASK-FORCE; INAPPROPRIATE SHOCKS; EUROPEAN-SOCIETY; PREVENTION; OUTCOMES; THERAPY; ICD; ASSOCIATION;
D O I
10.1093/europace/euad270
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims The implantable cardioverter-defibrillator (ICD) is a life-saving therapy in patients with hypertrophic cardiomyopathy (HCM) at risk of sudden cardiac death. Implantable cardioverter-defibrillator complications are of concern. The subcutaneous ICD (S-ICD) does not use transvenous leads and is expected to reduce complications. However, it does not provide bradycardia and anti-tachycardia pacing (ATP). The aim of this study was to compare appropriate and inappropriate ICD interventions, complications, disease-related adverse events and mortality between HCM patients implanted with a S- or transvenous (TV)-ICD.Methods and results Consecutive HCM patients implanted with a S- (n = 216) or TV-ICD (n = 211) were enrolled. Propensity-adjusted cumulative Kaplan-Meier curves and multivariate Cox proportional hazard ratios were used to compare 5-year event-free survival and the risk of events. The S-ICD patients had lower 5-year risk of appropriate (HR: 0.32; 95%CI: 0.15-0.65; P = 0.002) and inappropriate (HR: 0.44; 95%CI: 0.20-0.95; P = 0.038) ICD interventions, driven by a high incidence of ATP therapy in the TV-ICD group. The S- and TV-ICD patients experienced similar 5-year rate of device-related complications, albeit the risk of major lead-related complications was lower in S-ICD patients (HR: 0.17; 95%CI: 0.038-0.79; P = 0.023). The TV- and S-ICD patients displayed similar risk of disease-related complications (HR: 0.64; 95%CI: 0.27-1.52; P = 0.309) and mortality (HR: 0.74; 95%CI: 0.29-1.87; P = 0.521).Conclusion Hypertrophic cardiomyopathy patients implanted with a S-ICD had lower 5-year risk of appropriate and inappropriate ICD therapies as well as of major lead-related complications as compared to those implanted with a TV-ICD. Long-term comparative follow-up studies will clarify whether the lower incidence of major lead-related complications will translate into a morbidity or survival benefit. Graphical Abstract
引用
收藏
页数:9
相关论文
共 41 条
[1]   Ventricular fibrillation undersensing due to air entrapment in a patient implanted with a subcutaneous cardioverter defibrillator [J].
Adduci, Carmen ;
Spadoni, Loris ;
Palano, Francesca ;
Francia, Pietro .
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 2019, 30 (08) :1373-1374
[2]   Safety and efficacy of anti-tachycardia pacing in patients with hypertrophic cardiomyopathy implanted with an ICD [J].
Adduci, Carmen ;
Semprini, Lorenzo ;
Palano, Francesca ;
Musumeci, Maria Beatrice ;
Volpe, Massimo ;
Autore, Camillo ;
Francia, Pietro .
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 2019, 42 (06) :610-616
[3]  
Al-Khatib SM, 2018, CIRCULATION, V138, pE210, DOI [10.1161/CIR.0000000000000549, 10.1161/CIR.0000000000000548]
[4]   Air entrapment as a potential cause of early subcutaneous implantable cardioverter defibrillator malfunction: a systematic review of the literature [J].
Ali, Hussam ;
Lupo, Pierpaolo ;
Foresti, Sara ;
De Ambroggi, Guido ;
De Lucia, Carmine ;
Penela, Diego ;
Turturiello, Dario ;
Paganini, Edoardo Maria ;
Cappato, Riccardo .
EUROPACE, 2022, 24 (10) :1608-1616
[5]   Inappropriate shocks in single-chamber and subcutaneous implantable cardioverter-defibrillators: a systematic review and meta-analysis [J].
Auricchio, Angelo ;
Hudnall, J. Harrison ;
Schloss, Edward J. ;
Sterns, Laurence D. ;
Kurita, Takashi ;
Meijer, Albert ;
Fagan, Dedra H. ;
Rogers, Tyson .
EUROPACE, 2017, 19 (12) :1973-1980
[6]   Low inappropriate shock rates in patients with single- and dual/triple-chamber implantable cardioverter-defibrillators using a novel suite of detection algorithms: Pain Free SST trial primary results [J].
Auricchio, Angelo ;
Schloss, Edward J. ;
Kurita, Takashi ;
Meijer, Albert ;
Gerritse, Bart ;
Zweibel, Steven ;
AlSmadi, Faisal M. ;
Leng, Charles T. ;
Sterns, Laurence D. .
HEART RHYTHM, 2015, 12 (05) :926-936
[7]  
Basu-Ray Indranill, 2017, JACC Clin Electrophysiol, V3, P1475, DOI 10.1016/j.jacep.2017.07.017
[8]   Safety of Omitting Defibrillation Efficacy Testing With Subcutaneous Defibrillators: A Propensity-Matched Case-Control Study [J].
Bianchi, Valter ;
Bisignani, Giovanni ;
Migliore, Federico ;
Biffi, Mauro ;
Nigro, Gerardo ;
Viani, Stefano ;
Caravati, Fabrizio ;
Checchi, Luca ;
Francia, Pietro ;
De Filippo, Paolo ;
Pecora, Domenico ;
Lavalle, Carlo ;
Scalone, Antonio ;
Rossi, Pietro ;
Palmisano, Pietro ;
Licciardello, Giovanni ;
Ospizio, Roberto ;
Lovecchio, Mariolina ;
Valsecchi, Sergio ;
D'Onofrio, Antonio .
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 2021, 14 (12) :1091-1093
[9]   Implant and Midterm Outcomes of the Subcutaneous Implantable Cardioverter-Defibrillator Registry The EFFORTLESS Study [J].
Boersma, Lucas ;
Barr, Craig ;
Knops, Reinoud ;
Theuns, Dominic ;
Eckardt, Lars ;
Neuzil, Petr ;
Scholten, Marcoen ;
Hood, Margaret ;
Kuschyk, Juergen ;
Jones, Paul ;
Duffy, Elizabeth ;
Husby, Michael ;
Stein, Kenneth ;
Lambiase, Pier D. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2017, 70 (07) :830-841
[10]   Intermuscular technique for implantation of the subcutaneous implantable defibrillator: a propensity-matched case-control study [J].
Botto, Giovanni Luca ;
Ziacchi, Matteo ;
Nigro, Gerardo ;
D'Onofrio, Antonio ;
Dello Russo, Antonio ;
Francia, Pietro ;
Viani, Stefano ;
Pisano, Ennio ;
Bisignani, Giovanni ;
Caravati, Fabrizio ;
Migliore, Federico ;
De Filippo, Paolo ;
Ottaviano, Luca ;
Rordorf, Roberto ;
Manzo, Michele ;
Canevese, Fabio Lorenzo ;
Lovecchio, Mariolina ;
Valsecchi, Sergio ;
Checchi, Luca .
EUROPACE, 2023, 25 (04) :1423-1431