Risk of all-cause and cardiac-related mortality after vaccination against COVID-19: A meta-analysis of self-controlled case series studies

被引:7
作者
Marchand, Greg [1 ,4 ]
Masoud, Ahmed Taher [1 ,2 ]
Medi, Sai [3 ]
机构
[1] Marchand Inst Minimally Invas Surg, Mesa, AZ USA
[2] Fayoum Univ, Fac Med, Al Fayyum, Egypt
[3] Swedish Med Ctr, Englewood, CO USA
[4] Marchand Inst Minimally Invas Surg, 10238 E Hampton, Ste 212, Mesa, AZ 85209 USA
关键词
COVID19; vaccination; all-cause mortality; cardiac mortality; mRNA vaccination; self controlled case series; meta-analysis; ADOLESCENTS; MYOCARDITIS; SAFETY; US;
D O I
10.1080/21645515.2023.2230828
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Self-controlled case series (SCCS) is a novel study design uniquely equipped to ethically quantify the safety of vaccination. We sought out to perform a meta-analysis on all SCCS assessing mortality associated with COVID-19 vaccination in the immediate post-vaccination period. We included SCCS investigating the safety of COVID-19 vaccination and reporting all-cause and cardiac-related mortality. Three SCCS were located, totaling approximately 750,000 patients. The pooled hazard ratio (HR) revealed no significant association of COVID-19 vaccination with all-cause mortality (HR = 0.89, 95% CI [0.71, 1.10], p = .28). Regarding cardiac-related mortality, the pooled HR suggests that COVID-19 vaccination is associated with an increased risk of cardiac-related mortality (HR = 1.06, 95% CI [1.02, 1.11], p = .007). Subgroup analysis showed that the male gender is significantly associated with an increased incidence of cardiac-related deaths (HR = 1.09, 95% CI [1.02, 1.15], p = .006). In conclusion, COVID-19 vaccination may be associated with a small increase in cardiac-related mortality, especially among males. Prospero Prospective Registration Number: CRD42022372256
引用
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页数:6
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