Steroid-Refractory Chronic Graft-Versus-Host Disease: Treatment Options and Nursing Care

BACKGROUND: Chronic graft-versus-host disease (cGVHD) is a significant complication for patients who receive allogeneic hematopoietic stem cell transplantation. This disease is further complicated for patients who are refractory to steroids. This article reviews emerging therapies and supportive care for patients with steroid-refractory cGVHD.OBJECTIVES:This article provides foundational knowledge on steroid-refractory cGVHD, emerg-ing treatment options, and related supportive care.METHODS: Current research on emerging therapies for patients with steroid-refractory cGVHD is summarized along with supportive care recommendations and a review of related nursing considerations.FINDINGS: Emerging therapies for steroid -refractory cGVHD offer opportunities for improved clinical outcomes for these patients. Nursing knowledge of new therapies and supportive care for patients with steroid-refractory cGVHD supports the provision of optimal nursing care for a complex population of patients.