Determination of orally administered 1,8-Cineol in nasal polyp tissues from chronic rhinosinusitis patients using gas chromatography: mass spectrometry

被引：8

作者：

MacKenzie, Claire ^{[1
]}

Goerke, Thomas ^{[2
]}

Buecking, Mark ^{[1
]}

Heidemann, Mathias ^{[3
]}

Leichtle, Anke ^{[3
]}

Ringbeck, Benedikt ^{[1
]}

Moellenkolk, Friederike ^{[3
]}

Ploch, Michael ^{[2
]}

Bruchhage, Karl-Ludwig ^{[3
]}

Pries, Ralph ^{[3
]}

机构：

[1] Fraunhofer Inst Mol Biol & Appl Ecol IME, Schmallenberg, Germany

[2] Klosterfrau Healthcare Grp, Berlin, Germany

[3] Univ Hosp Schleswig Holstein, Dept Otorhinolaryngol, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany

来源：

SCIENTIFIC REPORTS | 2023年 / 13卷 / 01期

关键词：

ESSENTIAL OILS; SUPERANTIGENS; EUCALYPTOL; ENZYMES; HUMANS;

D O I：

10.1038/s41598-023-29941-x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disease causing considerable disease burden. The anti-inflammatory monoterpene 1,8-Cineol is a natural plant-based therapeutic agent that is well established to treat chronic and acute airway diseases. Aim of this study was to investigate whether the herbal drug 1,8-Cineol reaches the nasal tissue via the gut and the blood stream upon its oral administration. A highly sensitive gas chromatography mass spectrometry-based method with stir bar sorptive extraction (SBSE) for sample preparation has been developed and validated for the extraction, detection and quantification of 1,8-Cineol in tissue samples of nasal polyps from 30 CRSwNP patients. Data revealed a highly sensitive detection of 1,8-Cineol in nasal tissue samples after 14 days of oral administration of 1,8-Cineol prior to surgical treatment. There was no significant correlation between the measured 1,8-Cineol concentrations and bodyweight or BMI values of the analyzed patients, respectively. Our data indicate a systemic distribution of 1,8-Cineol in the human body after its oral administration. Individual differences in terms of metabolic characteristics and have to be further investigated. The study increases our understanding of the systemic effects of 1,8-Cineol upon its therapeutic application and benefit in patients with CRSwNP.

引用

页数：7

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