Adjuvant treatment of in-transit melanoma: Narrowing the knowledge gap left by clinical trials

被引：0

作者：

de Meza, Melissa M. ^{[1
,2
,3
]}

Blokx, Willeke A. M. ^{[4
]}

Bonenkamp, Han J. ^{[5
]}

Blank, Cristian U. ^{[6
]}

Aarts, Maureen J. B. ^{[7
]}

van den Berkmortel, Franchette W. P. J. ^{[8
]}

Boers-Sonderen, Marye J. ^{[9
]}

de Groot, Jan Willem B. ^{[10
]}

Haanen, John B. ^{[11
]}

Hospers, Geke A. P. ^{[12
]}

Kapiteijn, Ellen W. ^{[11
]}

van Not, Olivier J. ^{[13
]}

Piersma, Djura ^{[14
]}

van Rijn, Rozemarijn S. ^{[15
]}

Boer, Marion A. Stevense-Den A. ^{[16
]}

van Der Veldt, Astrid A. M. ^{[17
,18
]}

Vreugdenhil, Gerard ^{[19
]}

van den Eertwegh, Alfons J. M.

Suijkerbuijk, Karijn P. M. ^{[13
]}

Wouters, Michel W. J. M. ^{[1
,2
,3
]}

机构：

[1] Dutch Inst Clin Auditing, Leiden, Netherlands

[2] Leiden Univ, Dept Biomed Data Sci, Med Ctr, NL-2333 ZA Leiden, Netherlands

[3] Netherlands Canc Inst, Dept Surg Oncol, Amsterdam, Netherlands

[4] Univ Med Ctr Utrecht, Dept Pathol, Utrecht, Netherlands

[5] Radboud Univ Nijmegen, Dept Surg, Med Ctr, Nijmegen, Netherlands

[6] Netherlands Canc Inst, Dept Med Oncol & Immunol, Amsterdam, Netherlands

[7] Maastricht Univ, GROW Sch Oncol & Reprod, Dept Med Oncol, Med Ctr, Maastricht, Netherlands

[8] Zuyderland Med Ctr Sittard, Dept Med Oncol, Sittard Geleen, Netherlands

[9] Radboud Univ Nijmegen, Dept Med Oncol, Med Ctr, Nijmegen, Netherlands

[10] Isala Oncol Ctr, Canc Ctr Amsterdam, Dept Med Oncol, Amsterdam UMC, Zwolle, Netherlands

[11] Leiden Univ, Dept Med Oncol, Med Ctr, Leiden, Netherlands

[12] Univ Groningen, Univ Med Ctr Groningen, Dept Med Oncol, Groningen, Netherlands

[13] Univ Med Ctr Utrecht, Dept Med Oncol, Utrecht, Netherlands

[14] Med Spectrum Twente, Dept Internal Med, Enschede, Netherlands

[15] Med Ctr Leeuwarden, Dept Internal Med, Leeuwarden, Netherlands

[16] Amphia Hosp, Dept Internal Med, Breda, Netherlands

[17] Erasmus MC, Dept Med Oncol & Radiol, Rotterdam, Netherlands

[18] Erasmus MC, Dept Nucl Med, Rotterdam, Netherlands

[19] Maxima Med Ctr, Dept Internal Med, Eindhoven, Netherlands

来源：

INTERNATIONAL JOURNAL OF CANCER | 2023年 / 153卷 / 02期

关键词：

adjuvant treatment; melanoma; checkpoint inhibition therapy; immunotherapy; in-transit melanoma; METASTASES; IPILIMUMAB; NIVOLUMAB;

D O I：

10.1002/ijc.34485

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Few clinical trials address efficacy of adjuvant systemic treatment in patients with in-transit melanoma (ITM). This study describes adjuvant systemic therapy of ITM patients beyond clinical trials. In this study, we included stage III adjuvant-treated melanoma patients registered in the nationwide Dutch Melanoma Treatment Registry between July 2018 and December 2020. Patients were divided into three groups: nodal disease only, ITM only and ITM and nodal disease. Recurrence patterns, recurrence-free survival (RFS) and overall survival (OS) at 12-months were analyzed. In our study population of 1037 patients, 66.8% had nodal disease only, 16.7% had ITM only and 16.2% had ITM with nodal disease. RFS at 12-months was comparable in the nodal only and ITM only group (72.2% vs70.1%, P = .97) but lower in ITM and nodal disease patients (57.8%; P = .01, P < .01). Locoregional metastases occurred as first recurrence in 38.9% nodal disease only, 71.9% of ITM-only and 44.0% of ITM and nodal disease patients. Distant recurrences occurred in 42.3%, 18.8% and 36.0%, respectively (P = .02). 12-months OS was not significantly different for nodal disease only patients compared with ITM-only (94.4% vs 97.6%, P = .06) but was significantly higher for ITM-only compared with ITM and nodal disease patients (97.6% vs 91.0%, P < .01). In conclusion, we showed that in the adjuvant setting, RFS rates in ITM-only patients are similar to non-ITM, though better than in ITM and nodal disease patients. Adjuvant-treated ITM-only patients less often experience distant recurrences and have a superior OS compared with ITM and nodal disease patients.

引用

页码：389 / 398

页数：10

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