Hemophagocytic Lymphohistiocytosis Following COVID-19 Infection

被引:2
|
作者
Molina, Guarina [1 ]
Contreras, Rafael [1 ]
Coombes, Kyle [2 ]
Walgamage, Thilini [1 ]
Perozo, Maria A. [1 ]
DesBiens, Martha T. [3 ]
机构
[1] Danbury Hosp, Internal Med, Danbury, CT 06810 USA
[2] Amer Univ Caribbean, Sch Med, Cupecoy, Sint Maarten
[3] Danbury Hosp, Infect Dis, Danbury, CT USA
关键词
disseminated intravascular coagulation (dic); soluble interleukin receptors; inflammatory mediators; pancytopenia; hemophagocytic lymphohistiocytosis (hlh); covid; 19;
D O I
10.7759/cureus.34307
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with multiple inflammatory symptoms involving several organ systems, including hematologic manifestations. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome caused by excessive inflammation in the absence of immune regulation. We present the case of a patient with HLH secondary to dysregulated inflammatory response following COVID-19; we also describe the diagnostic and management challenges associated with the condition.
引用
收藏
页数:8
相关论文
共 50 条
  • [31] REDUCED INCIDENCE OF HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN JAPAN DURING THE COVID-19 PANDEMIC
    Sakamoto, Kenichi
    Ono, Rintaro
    Doi, Takehiko
    Koga, Yuhki
    Shioda, Yoko
    PEDIATRIC BLOOD & CANCER, 2023, 70 : S40 - S41
  • [32] Hemophagocytic lymphohistiocytosis in a patient with COVID-19 treated with tocilizumab: a case report
    Birgitte Tholin
    Marit Teigen Hauge
    Pål Aukrust
    Lutz Fehrle
    Tor Henrik Tvedt
    Journal of Medical Case Reports, 14
  • [33] Reduced incidence of hemophagocytic lymphohistiocytosis in Japan during the COVID-19 pandemic
    Sakamoto, Kenichi
    Ono, Rintaro
    Doi, Takehiko
    Koga, Yuhki
    Shioda, Yoko
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2022, 115 (03) : 446 - 448
  • [34] A rare case of post COVID-19 hemophagocytic lymphohistiocytosis in a pediatric patient
    Rjoop, A.
    Barukba, M.
    Al Rusan, O.
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2021, 156 : S93 - S93
  • [35] WHEN COVID-19 AND HIV JOIN FORCES TO TRIGGER HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
    Ramirez, Claudia
    Gonzalez, Paula
    Sanekommu, Harshavardhan
    Angelova, Evgeniya
    Patel, Purvi
    Abu Homoud, Ahmad
    Tafa, Medin
    CHEST, 2023, 164 (04) : 2647A - 2648A
  • [36] A histopathological observation regarding the possibility of hemophagocytic lymphohistiocytosis in COVID-19 patients
    Abdollahi, Alireza
    Beigmohammadi, Mohammad Taghi
    Safaei, Masoomeh
    Mehrtash, Vahid
    Jafarzadeh, Bita
    JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES, 2020, 29 (03) : 475 - 476
  • [37] Could hemophagocytic lymphohistiocytosis be the core issue of severe COVID-19 cases?
    Opoka-Winiarska, Violetta
    Grywalska, Ewelina
    Rolinski, Jacek
    BMC MEDICINE, 2020, 18 (01)
  • [38] Could hemophagocytic lymphohistiocytosis be the core issue of severe COVID-19 cases?
    Violetta Opoka-Winiarska
    Ewelina Grywalska
    Jacek Roliński
    BMC Medicine, 18
  • [39] Hemophagocytic Lymphohistiocytosis Secondary to Acute Human Immunodeficiency Virus and COVID-19
    Chowdhury, Selia
    Sanekommu, Harshavardhan
    Gonzalez, Paula
    Angelova, Evgeniya
    Patel, Swapnil
    JOURNAL OF MEDICAL CASES, 2024, 15 (09) : 222 - 226
  • [40] COVID-19 AND A HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS-LIKE SYNDROME IN THE ABSENCE OF ARDS
    White, Kyle
    Benninger, Lauryn
    Manjarres, Diana Gomez
    CHEST, 2020, 158 (04) : 1007A - 1007A