Anticancer properties of bromelain: State-of-the-art and recent trends

被引：28

作者：

Pezzani, Raffaele ^{[1
,2
]}

Jimenez-Garcia, Manuel ^{[3
]}

Capo, Xavier ^{[4
,5
]}

Sonmez Gurer, Eda ^{[6
]}

Sharopov, Farukh ^{[7
]}

Rachel, Tchokouaha Yamthe Lauve ^{[8
]}

Ntieche Woutouoba, David ^{[9
]}

Rescigno, Antonio ^{[10
]}

Peddio, Stefania ^{[10
]}

Zucca, Paolo ^{[10
]}

Tsouh Fokou, Patrick Valere ^{[11
]}

Martorell, Miquel ^{[12
,13
]}

Gulsunoglu-Konuskan, Zehra ^{[14
]}

Ydyrys, Alibek ^{[15
,16
]}

Bekzat, Tynybekov ^{[17
]}

Gulmira, Tussupbekova ^{[18
]}

Hano, Christophe ^{[19
]}

Sharifi-Rad, Javad ^{[20
]}

Calina, Daniela ^{[21
]}

机构：

[1] Univ Padua, Dept Med DIMED, Endocrinol Unit, Phytotherapy Lab, Padua, Italy

[2] Assoc Italiana Ric Oncolog Base AIROB, Padua, Italy

[3] Univ Balear Isl UIB, Biol Dept, Lab Neurophysiol, Palma De Mallorca, Spain

[4] Univ Balear Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain

[5] Univ Balear Isl, Hlth Res Inst Balear Islands IdISBa, Palma De Mallorca, Spain

[6] Sivas Cumhuriyet Univ, Fac Pharm, Dept Pharmacognosy, Sivas, Turkiye

[7] Natl Acad Sci Tajikistan, Res Inst Chinese Tajik Innovat Ctr Nat Prod, Dushanbe, Tajikistan

[8] Inst Med Res & Med Plants Studies IMPM, Yaounde, Cameroon

[9] Univ Yaounde, Fac Sci, Dept Biochem, Antimicrobial & Biocontrol Agents Unit, Yaounde, Cameroon

[10] Univ Cagliari, Dept Biomed Sci, Cagliari, Italy

[11] Univ Bamenda, Fac Sci, Dept Biochem, Bambili, Cameroon

[12] Univ Concepcion, Fac Pharm, Ctr Hlth Living, Dept Nutr & Dietet, Concepcion, Chile

[13] Univ Concepcion, Unidad Desarrollo Tecnol, Concepcion, Chile

[14] Istanbul Aydin Univ, Fac Hlth Sci, Nutr & Dietet Dept, Istanbul, Turkiye

[15] Al Farabi Kazakh Natl Univ, Biomed Res Ctr, Alma Ata, Kazakhstan

[16] George Washington Univ, Elliott Sch Int Affairs, Washington, DC USA

[17] Al Farabi Kazakh Natl Univ, Dept Biodivers & Bioresources, Alma Ata, Kazakhstan

[18] Al Farabi Kazakh Natl Univ, Dept Biophys Biomed & Neurosci, Alma Ata, Kazakhstan

[19] Univ Orleans, Dept Biol Chem, Chartres, France

[20] Univ Azuay, Fac Med, Cuenca, Ecuador

[21] Univ Med & Pharm Craiova, Dept Clin Pharm, Craiova, Romania

来源：

FRONTIERS IN ONCOLOGY | 2023年 / 12卷

关键词：

bromelain; cancer; chemotherapeutics; cytotoxicity; apoptosis; molecular targets; INDUCED CYTOKINE PRODUCTION; IN-VITRO; CYSTEINE PROTEINASES; PROTEOLYTIC-ENZYME; SURFACE MOLECULES; FRUIT BROMELAIN; PINEAPPLE STEMS; ANANAS-COMOSUS; T-CELL; PURIFICATION;

D O I：

10.3389/fonc.2022.1068778

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bromelain is a key enzyme found in pineapple (Ananas comosus (L.) Merr.); a proteolytic substance with multiple beneficial effects for human health such as anti-inflammatory, immunomodulatory, antioxidant and anticarcinogenic, traditionally used in many countries for its potential therapeutic value. The aim of this updated and comprehensive review focuses on the potential anticancer benefits of bromelain, analyzing the cytotoxic, apoptotic, necrotic, autophagic, immunomodulating, and anti-inflammatory effects in cancer cells and animal models. Detailed information about Bromelain and its anticancer effects at the cellular, molecular and signaling levels were collected from online databases such as PubMed/MedLine, TRIP database, GeenMedical, Scopus, Web of Science and Google Scholar. The results of the analyzed studies showed that Bromelain possesses corroborated pharmacological activities, such as anticancer, anti-edema, anti-inflammatory, anti-microbial, anti-coagulant, anti-osteoarthritis, anti-trauma pain, anti-diarrhea, wound repair. Nonetheless, bromelain clinical studies are scarce and still more research is needed to validate the scientific value of this enzyme in human cancer diseases.

引用

页数：18

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