Coumestrol attenuates dexamethasone-induced muscle atrophy via AMPK-FOXO1/3 signaling

被引：5
作者：
Hah, Young-Sool [1 ,2 ]
Lee, Won Keong [2 ]
Lee, Sangyeob [2 ,3 ]
Seo, Jin-Hee [4 ]
Kim, Eun Ji [1 ]
Choe, Yeong-in [1 ]
Kim, Sang Gon [5 ]
Yoo, Jun-Il [1 ,6 ]
机构：
[1] Gyeongsang Natl Univ, Sch Med & Hosp, Inst Hlth Sci, Dept Orthoped, Jinju, South Korea
[2] Gyeongsang Natl Univ Hosp, Biomed Res Inst, Jinju, South Korea
[3] Gyeongsang Natl Univ, Coll Vet Med, Dept Theriogenol & Biotechnol, Jinju, South Korea
[4] Rular Dev Adm, Natl Inst Crop Sci, Crop Prod Technol Res Div, Miryang, South Korea
[5] Gyeongnam Oriental Antiaging Inst, Antiaging Res Grp, Sancheong, South Korea
[6] Gyeongsang Natl Univ Hosp, Dept Orthopaed Surg, 90 Chilamdong, Jinju 660702, Gyeongnamdo, South Korea
来源：
JOURNAL OF FUNCTIONAL FOODS | 2023年 / 100卷
关键词：
Coumestrol; Dexamethasone; Muscle atrophy; FoxO1; 3; MuRF1; MAFbx; OXIDATIVE STRESS; SARCOPENIA; INFLAMMATION; AUTOPHAGY; ALPHA; MASS;
D O I：
10.1016/j.jff.2022.105387
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Sarcopenia is the loss of muscular mass and strength as a person ages, resulting in considerable impairment in daily functions and an increased risk of falls and fractures, finally leading to loss of independence. Coumestrol has been known to have an effect on the inhibition of skeletal muscle loss, but the coumestrol protection mechanism is poorly understood. To investigate the protective effect of coumestrol against dexamethasone-induced muscle atrophy, in vitro and in vivo analysis was performed through dexamethasone-induced muscle atrophy mouse model and C2C12 myoblasts. As a results, coumestrol might attenuate the dexamethasone-induced muscle atrophy via blocking the ubiquitin-proteasome pathway induced by suppressing AMPK-FoxO1/3 signaling. Therefore, coumestrol would be a potential treatment agents for aging sarcopenia.
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页数：9
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