Controlled drug delivery mediated by cyclodextrin-based supramolecular self-assembled carriers: From design to clinical performances

The need for solutions in the pharmaceutical field that respond to the new needs regarding the minimum impact of the active pharmaceutical substances on the body has led to an explosion of research on smart systems for controlled drug delivery. Supramolecular chemistry has provided in recent years powerful tools in the field of synthesis of these forms for controlled release, cyclodextrins offering the possibility for synthesis of complex supramolecular architectures that meet these requirements. But cyclodextrins can be used only with a carrier in order to benefit by their excellent properties and this review presents the latest achievements in the field of nanoparticles-based supramolecular architectures, taken into account the main methods of synthesis and the stimuli that control the release (light-responsive, pH-responsive, redox-responsive, and multi-responsive). The review also presents applications of these systems for cooperative co-delivery systems, non-viral vectors for gene delivery and theranostics and also the present status regarding commercial systems based on cyclodextrins and their characteristics.