Multiple Roles of PLK1 in Mitosis and Meiosis

被引:31
|
作者
Kalous, Jaroslav [1 ]
Aleshkina, Daria [1 ]
机构
[1] Czech Acad Sci, Inst Anim Physiol & Genet, Libechov 27721, Czech Republic
关键词
polo-like kinase 1; PLK1; mitosis; meiosis; spindle; oocytes; mRNA translation; POLO-LIKE KINASE; ANAPHASE-PROMOTING COMPLEX; NUCLEAR-PORE COMPLEXES; MEIOTIC MATURATION; CHROMOSOME COMPACTION; CENTROSOME PROTEIN; BOX DOMAIN; PHOSPHORYLATION; ACTIVATION; POLO-LIKE-KINASE-1;
D O I
10.3390/cells12010187
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cells are equipped with a diverse network of signaling and regulatory proteins that function as cell cycle regulators and checkpoint proteins to ensure the proper progression of cell division. A key regulator of cell division is polo-like kinase 1 (PLK1), a member of the serine/threonine kinase family that plays an important role in regulating the mitotic and meiotic cell cycle. The phosphorylation of specific substrates mediated by PLK1 controls nuclear envelope breakdown (NEBD), centrosome maturation, proper spindle assembly, chromosome segregation, and cytokinesis. In mammalian oogenesis, PLK1 is essential for resuming meiosis before ovulation and for establishing the meiotic spindle. Among other potential roles, PLK1 regulates the localized translation of spindle-enriched mRNAs by phosphorylating and thereby inhibiting the translational repressor 4E-BP1, a downstream target of the mTOR (mammalian target of rapamycin) pathway. In this review, we summarize the functions of PLK1 in mitosis, meiosis, and cytokinesis and focus on the role of PLK1 in regulating mRNA translation. However, knowledge of the role of PLK1 in the regulation of meiosis remains limited.
引用
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页数:15
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