Advances in the Synthesis of Fused 1,2,3-Triazoles via a MCR-Intramolecular Azide-Alkyne Cycloaddition Approach

被引：6

作者：

Rahul, P. ^{[1
,2
]}

Thomas, Joice ^{[3
]}

Dehaen, Wim ^{[4
]}

John, Jubi ^{[1
,2
]}

机构：

[1] CSIR Natl Inst Interdisciplinary Sci & Technol CSI, Chem Sci & Technol Div, Thiruvananthapuram 695019, India

[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India

[3] Univ Southern Calif, Bridge USC & Loker Hydrocarbon Res Inst, Los Angeles, CA 90089 USA

[4] Dept Chem, Mol Design & Synth, KU Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium

来源：

MOLECULES | 2023年 / 28卷 / 01期

关键词：

1; 2; 3-triazole; multicomponent reaction; intramolecular azide-alkyne cycloaddition; dipolar cycloaddition; ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; CLICK CHEMISTRY; DERIVATIVES; 4-COMPONENT; PROTOCOL; ANALOGS;

D O I：

10.3390/molecules28010308

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present review narrates several reports which deal with the synthesis of fused 1,2,3-triazole containing scaffolds following a sequential multicomponent reaction (MCR)-intramolecular azide-alkyne cycloaddition (IAAC) approach. The reviewed reactions were cleverly designed so as to incorporate azide and alkyne functionalities in the MCR product which was then subjected to IAAC. The review is divided into two sections based on the number of components in the multicomponent reaction. We have aimed at a critical discussion and also have highlighted either advantages or disadvantages of each methodology.

引用

页数：20

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