Chemical profile and toxicogenetic safety assessment of Smallanthus sonchifolius (yacon) organic extracts

被引：1
作者：
Szokalo, Rocio Ayelen Moreira [1 ,2 ]
Ulloa, Jeronimo [3 ]
Tulino, Maria Soledad [1 ,2 ]
Redko, Flavia [3 ]
Flor, Sabrina [4 ,5 ]
Muschietti, Liliana [3 ,6 ]
Carballo, Marta A. [1 ,2 ]
机构：
[1] Univ Buenos Aires, Fac Farm & Bioquim, Dept Bioquim Clin, CIGETOX,Citogenet Humana & Genet Toxicol, Junin 956, RA-1113 Buenos Aires, Argentina
[2] Univ Buenos Aires, Fac Farm & Bioquim, Inst Fisiopatol & Bioquim Clin INFIBIOC, Cordoba 2351, RA-1120 Buenos Aires, Argentina
[3] Univ Buenos Aires, Fac Farm & Bioquim, Dept Farmacol, Catedra Farmacognosia, Junin 956, RA-1113 Buenos Aires, Argentina
[4] Univ Buenos Aires, Fac Farm & Bioquim, Dept Tecnol Farmaceut, Junin 956, RA-1113 Buenos Aires, Argentina
[5] Consejo Nacl Invest Cient & Tecn, Consejo Nacl Invest Cient & Tecnol, Buenos Aires, Argentina
[6] Univ Buenos Aires, Fac Farm & Bioquim, Buenos Aires, Argentina
来源：
NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 22期
关键词：
Smallanthus sonchifolius; ethanol extract; sesquiterpene lactones; genotoxicity; cytotoxicity; INHIBITION;
D O I：
10.1080/14786419.2022.2153361
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The interest in Smallanthus sonchifolius (yacon) has strongly resurfaced due to its multiple beneficial effects on human health. This study aimed at determining the toxicity and the chemical profile of an ethanol extract (EE) and a crude lactone mixture (CLM) of yacon leaves. Cytotoxicity and genotoxicity tests were performed by the MTT assay and the alkaline version of the comet assay respectively. The phytochemical analysis, performed by chromatographic and spectroscopy techniques, revealed the presence of nine sesquiterpene lactones (STLs) and two acyclic diterpene acids. In all cases, cell viability was inversely proportional to the extract concentration employed. The effects obtained with the highest dose of EE were significantly different from those obtained with the negative and solvent controls. Conversely, no significant differences were observed between the lowest doses of EE and controls. As for CLM, all tested doses showed statistically significant increases, as compared to negative and solvent controls.
引用
收藏
页码：3868 / 3872
页数：5
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