Slow Waning of Antibodies Following BNT162b2 as a Third Dose in Adults Who Had Previously Received 2 Doses of Inactivated Vaccine

被引：5

作者：

Cowling, Benjamin J. ^{[1
,2
]}

Cheng, Samuel M. S. ^{[1
]}

Martin-Sanchez, Mario ^{[1
]}

Au, Niki Y. M. ^{[1
]}

Chan, Karl C. K. ^{[1
]}

Li, John K. C. ^{[1
]}

Fung, Lison W. C. ^{[1
]}

Luk, Leo L. H. ^{[1
]}

Tsang, Leo C. H. ^{[1
]}

Ip, Dennis K. M. ^{[1
]}

Poon, Leo L. M. ^{[1
,3
,4
]}

Leung, Gabriel M. ^{[1
,2
]}

Peiris, J. S. Malik ^{[1
,3
,4
]}

Leung, Nancy H. L. ^{[1
,2
]}

机构：

[1] Univ Hong Kong, Li Ka Shing Fac Med, WHO Collaborating Ctr Infect Dis Epidemiol & Cont, Sch Publ Hlth,Pokfulam, Hong Kong, Peoples R China

[2] Hong Kong Sci & Technol Pk, Lab Data Discovery Hlth, Hong Kong, Peoples R China

[3] Univ Hong Kong, Univ Hong Kong Pasteur Res Pole, Li Ka Shing Fac Med, Sch Publ Hlth,Pokfulam, Hong Kong, Peoples R China

[4] Hong Kong Sci & Technol Pk, Ctr Immunol & Infect, Hong Kong, Peoples R China

来源：

JOURNAL OF INFECTIOUS DISEASES | 2023年 / 227卷 / 02期

关键词：

BNT162b2; COVID-19; antibody; CoronaVac; immunogenicity;

D O I：

10.1093/infdis/jiac380

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We administered BNT162b2 as a third dose to 314 adults aged >= 30 years who had previously received 2 doses of inactivated vaccine. We collected blood samples before the third dose and again after 1 month and 6 months, and found robust antibody responses to the ancestral strain at 6 months after receipt of BNT162b2. Antibody responses to Omicron BA.2 by live virus neutralization were weaker after the third dose and had declined to a low level by 6 months.

引用

页码：251 / 255

页数：5

共 15 条

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