Relationship between childhood maltreatment and cognitive function in medication-free patients with major depressive disorder

被引：7

作者：

Guo, Weilong ^{[1
]}

Liu, Jin ^{[1
]}

Liu, Bangshan ^{[1
]}

Wang, Mi ^{[1
]}

Dong, Qiangli ^{[1
]}

Lu, Xiaowen ^{[1
]}

Sun, Jinrong ^{[1
]}

Zhang, Liang ^{[1
]}

Guo, Hua ^{[2
]}

Zhao, Futao ^{[2
]}

Li, Weihui ^{[1
]}

Li, Zexuan ^{[1
]}

Liao, Mei ^{[1
]}

Zhang, Li ^{[1
]}

Zhang, Yan ^{[1
]}

Ju, Yumeng ^{[1
]}

Li, Lingjiang ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Dept Psychiat, Changsha 410011, Hunan, Peoples R China

[2] Zhumadian Psychiat Hosp, Zhumadian 463000, Henan, Peoples R China

来源：

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2023年 / 273卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Major depressive disorder; Childhood maltreatment; Cognitive function; Memory; HIPPOCAMPAL ATROPHY; AUTOBIOGRAPHICAL MEMORY; METAANALYSIS; DEFICITS; NEGLECT; TRAUMA; MATTER; 1ST-EPISODE; ASSOCIATION; EXPERIENCES;

D O I：

10.1007/s00406-022-01458-w

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study aimed to elucidate the contribution of childhood maltreatment (CM) and the disease of major depressive disorder (MDD) on cognitive function in medication-free patients in a current depressive episode, and to examine the effect of CM on the improvement of cognitive function after treatment with antidepressants. One hundred and fifty-three unmedicated patients with MDD and 142 healthy controls (HCs) underwent clinical interviews. CM assessment was performed using the Childhood Trauma Questionnaire (CTQ), and a battery of comprehensive neurocognitive tests was used to assess the participants' executive function, processing speed, attention, and memory. After 6 months of treatment with antidepressants, the neurocognitive tests were reperformed in patients with MDD and HCs. There was a significant main effect of MDD on all four cognitive domains, while the main effect of CM was only significant on memory. No significant interactive effect was found between MDD and CM on any of the cognitive domains. In the MDD group, higher CTQ total score was predictive of poorer memory performance. After treatment, significant main effects of treatment and MDD were found on all four cognitive domains in remitted patients with MDD. No significant main effect of CM or three-way interaction effect of treatment x MDD x CM was found on any of the cognitive domains. The disease of MDD contributed to impairments in all four cognitive domains. CM independently contributed to memory impairment in patients in a current depressive episode, with higher severity of CM predictive of poorer memory performance.

引用

页码：1073 / 1083

页数：11

共 50 条

[1] Overgeneral autobiographical memory in women: Association with childhood abuse and history of depression in a community sample [J].

Aglan, Azza ;

Williams, J. Mark G. ;

Pickles, Andrew ;

Hill, Jonathan .

BRITISH JOURNAL OF CLINICAL PSYCHOLOGY, 2010, 49 :359-372

[2] Cognitive Functioning in the First-Episode of Major Depressive Disorder: A Systematic Review and Meta-Analysis [J].

Ahern, Elayne ;

Semkovska, Maria .

NEUROPSYCHOLOGY, 2017, 31 (01) :52-72

[3] State-dependent changes in hippocampal grey matter in depression [J].

Arnone, D. ;

McKie, S. ;

Elliott, R. ;

Juhasz, G. ;

Thomas, E. J. ;

Downey, D. ;

Williams, S. ;

Deakin, J. F. W. ;

Anderson, I. M. .

MOLECULAR PSYCHIATRY, 2013, 18 (12) :1265-1272

[4] Early Childhood Depression, Emotion Regulation, Episodic Memory, and Hippocampal Development [J].

Barch, Deanna M. ;

Harms, Michael P. ;

Tillman, Rebecca ;

Hawkey, Elizabeth ;

Luby, Joan L. .

JOURNAL OF ABNORMAL PSYCHOLOGY, 2019, 128 (01) :81-95

[5] The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology [J].

Belleau, Emily L. ;

Treadway, Michael T. ;

Pizzagalli, Diego A. .

BIOLOGICAL PSYCHIATRY, 2019, 85 (06) :443-453

[6] Neurocognitive predictors of antidepressant clinical response [J].

Bruder, Gerard E. ;

Alvarenga, Jorge E. ;

Alschuler, Daniel ;

Abraham, Karen ;

Keilp, John G. ;

Hellerstein, David J. ;

Stewart, Jonathan W. ;

McGrath, Patrick J. .

JOURNAL OF AFFECTIVE DISORDERS, 2014, 166 :108-114

[7] Childhood maltreatment and cognitive functioning in patients with major depressive disorder: a CAN-BIND-1 report [J].

Chakrabarty, Trisha ;

Harkness, Kate L. ;

McInerney, Shane J. ;

Quilty, Lena C. ;

Milev, Roumen V. ;

Kennedy, Sidney H. ;

Frey, Benicio N. ;

MacQueen, Glenda M. ;

Muller, Daniel J. ;

Rotzinger, Susan ;

Uher, Rudolf ;

Lam, Raymond W. .

PSYCHOLOGICAL MEDICINE, 2020, 50 (15) :2536-2547

[8] Adverse childhood experiences and the risk of depressive disorders in adulthood [J].

Chapman, DP ;

Whitfield, CL ;

Felitti, VJ ;

Dube, SR ;

Edwards, VJ ;

Anda, RF .

JOURNAL OF AFFECTIVE DISORDERS, 2004, 82 (02) :217-225

[9] Hippocampal atrophy in first episode depression: A meta-analysis of magnetic resonance imaging studies [J].

Cole, James ;

Costafreda, Sergi G. ;

McGuffin, Peter ;

Fu, Cynthia H. Y. .

JOURNAL OF AFFECTIVE DISORDERS, 2011, 134 (1-3) :483-487

[10] Presence of individual (residual) symptoms during depressive episodes and periods of remission: a 3-year prospective study [J].

Conradi, H. J. ;

Ormel, J. ;

de Jonge, P. .

PSYCHOLOGICAL MEDICINE, 2011, 41 (06) :1165-1174

← 1 2 3 4 5 →