Gene therapy with B-cell maturation antigen/CD3 bispecific antibody encoding plasmid DNA for treating multiple myeloma

被引：1

作者：

Peng, Fengping ^{[1
]}

Wang, Yuan ^{[2
,3
]}

Zhao, Jiliang ^{[2
,3
]}

Liu, Hui ^{[1
]}

Liu, Zhaoyun ^{[1
]}

Ding, Kai ^{[1
]}

Zhang, Hongkai ^{[2
,3
]}

Fu, Rong ^{[1
]}

机构：

[1] Tianjin Med Univ, Dept Hematol, Gen Hosp, Tianjin, Peoples R China

[2] Nankai Univ, State Key Lab Med Chem Biol, Tianjin, Peoples R China

[3] Nankai Univ, Coll Life Sci, Tianjin, Peoples R China

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2023年 / 201卷 / 03期

基金：

中国国家自然科学基金;

关键词：

B-cell maturation antigen; bispecific T-cell engager; gene therapy; in vivo electroporation; multiple myeloma;

D O I：

10.1111/bjh.18230

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The delivery of bispecific antibodies (BsAbs) targeting B-cell maturation antigen (BCMA) and CD3 using the gene therapy approach is a promising alternative for BsAb administration in patients with multiple myeloma (MM). In the present study, we evaluated the efficacy of this approach using a xenograft model. Tumour growth was significantly delayed in mice treated with single electroporation-enhanced intramuscular injection of plasmid DNA encoding BCMA/CD3 BsAb in contrast to the vehicle control-treated group. Limited toxicity was observed following treatment. This study demonstrates that the gene therapy-based approach for the delivery of BCMA/CD3 BsAb is effective and safe for the treatment of MM.

引用

页码：417 / 421

页数：5

共 15 条

[1] Immunotherapy Against HPV16/18 Generates Potent TH1 and Cytotoxic Cellular Immune Responses [J].

Bagarazzi, Mark L. ;

Yan, Jian ;

Morrow, Matthew P. ;

Shen, Xuefei ;

Parker, R. Lamar ;

Lee, Jessica C. ;

Giffear, Mary ;

Pankhong, Panyupa ;

Khan, Amir S. ;

Broderick, Kate E. ;

Knott, Christine ;

Lin, Feng ;

Boyer, Jean D. ;

Draghia-Akli, Ruxandra ;

White, C. Jo ;

Kim, J. Joseph ;

Weiner, David B. ;

Sardesai, Niranjan Y. .

SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (155)

[2] In Vivo Delivery of a DNA-Encoded Monoclonal Antibody Protects Non-human Primates against Zika Virus [J].

Esquivel, Rianne N. ;

Patel, Ami ;

Kudchodkar, Sagar B. ;

Park, Daniel H. ;

Stettler, Karin ;

Beltramello, Martina ;

Allen, Jeffrey W. ;

Mendoza, Janess ;

Ramos, Stephanie ;

Choi, Hyeree ;

Borole, Piyush ;

Asija, Kanika ;

Bah, Mamadou ;

Shaheen, Shareef ;

Chen, Jing ;

Yan, Jian ;

Durham, Amy C. ;

Smith, Trevor R. F. ;

Broderick, Kate ;

Guibinga, Ghiabe ;

Muthumani, Kar ;

Corti, Davide ;

Humeau, Laurent ;

Weiner, David B. .

MOLECULAR THERAPY, 2019, 27 (05) :974-985

[3] Intratumoral Plasmid IL12 Electroporation Therapy in Patients with Advanced Melanoma Induces Systemic and Intratumoral T-cell Responses [J].

Greaney, Samantha K. ;

Algazi, Alain P. ;

Tsai, Katy K. ;

Takamura, Kathryn T. ;

Chen, Lawrence ;

Twitty, Christopher G. ;

Zhang, Li ;

Paciorek, Alan ;

Pierce, Robert H. ;

Le, Mai H. ;

Daud, Adil, I ;

Fong, Lawrence .

CANCER IMMUNOLOGY RESEARCH, 2020, 8 (02) :246-254

[4] A Phase 1 First in Human (FIH) Study of AMG 701, an Anti-B-Cell Maturation Antigen (BCMA) Half-Life Extended (HLE) BiTE® (bispecific T-cell engager) Molecule, in Relapsed/Refractory (RR) Multiple Myeloma (MM) [J].

Harrison, Simon J. ;

Minnema, Monique C. ;

Lee, Hans C. ;

Spencer, Andrew ;

Kapoor, Prashant ;

Madduri, Deepu ;

Larsen, Jeremy ;

Ailawadhi, Sikander ;

Kaufman, Jonathan L. ;

Raab, Marc S. ;

Hari, Parameswaran ;

Iida, Shinsuke ;

Vij, Ravi ;

Davies, Faith E. ;

Lesley, Robin ;

Upreti, Vijay V. ;

Yang, Zhao ;

Sharma, Anjali ;

Minella, Alex ;

Lentzsch, Suzanne .

BLOOD, 2020, 136

[5] Development of Novel DNA-Encoded PCSK9 Monoclonal Antibodies as Lipid-Lowering Therapeutics [J].

Khoshnejad, Makan ;

Patel, Ami ;

Wojtak, Krzysztof ;

Kudchodkar, Sagar B. ;

Humeau, Laurent ;

Lyssenko, Nicholas N. ;

Rader, Daniel J. ;

Muthumani, Kar ;

Weiner, David B. .

MOLECULAR THERAPY, 2019, 27 (01) :188-199

[6] Gene therapy using plasmid DNA-encoded anti-HER2 antibody for cancers that overexpress HER2 [J].

Kim, H. ;

Danishmalik, S. N. ;

Hwang, H. ;

Sin, J-I ;

Oh, J. ;

Cho, Y. ;

Lee, H. ;

Jeong, M. ;

Kim, S-H ;

Hong, H. J. .

CANCER GENE THERAPY, 2016, 23 (10) :341-347

[7] Improved survival in multiple myeloma and the impact of novel therapies [J].

Kumar, Shaji K. ;

Rajkumar, S. Vincent ;

Dispenzieri, Angela ;

Lacy, Martha Q. ;

Hayman, Suzanne R. ;

Buadi, Francis K. ;

Zeldenrust, Steven R. ;

Dingli, David ;

Russell, Stephen J. ;

Lust, John A. ;

Greipp, Philip R. ;

Kyle, Robert A. ;

Gertz, Morie A. .

BLOOD, 2008, 111 (05) :2516-2520

[8] Regulated control of gene therapies by drug-induced splicing [J].

Monteys, Alex Mas ;

Hundley, Amiel A. ;

Ranum, Paul T. ;

Tecedor, Luis ;

Muehlmatt, Amy ;

Lim, Euyn ;

Lukashev, Dmitriy ;

Sivasankaran, Rajeev ;

Davidson, Beverly L. .

NATURE, 2021, 596 (7871) :291-+

[9] MEDICAL PROGRESS Multiple Myeloma [J].

Palumbo, Antonio ;

Anderson, Kenneth .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (11) :1046-1060

[10] Recent updates on bispecific T-cell engager (BiTE) antibodies in relapsed and refractory multiple myeloma. [J].

Rafae, Abdul ;

Wahab, Ahsan ;

Ehsan, Hamid ;

Christy, Joshua ;

Saleem, Tabinda ;

Kandah, Emad ;

Ali, Rabia ;

Malik, Mustafa Nadeem ;

Ali, Sundas ;

Saeed, Sara ;

Anwer, Faiz .

JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)

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