Non-coding RNA and reprogrammed mitochondrial metabolism in genitourinary cancer

被引：0

作者：

Thirunavukkarasu, Sandiya ^{[1
]}

Banerjee, Shouryarudra ^{[1
]}

Tantray, Ishaq ^{[2
,3
]}

Ojha, Rani ^{[1
]}

机构：

[1] Post Grad Inst Med Educ & Res, Dept Urol, Chandigarh, India

[2] InventX Scientia, Kashmir, India

[3] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA USA

来源：

FRONTIERS IN GENETICS | 2024年 / 15卷

关键词：

non-coding RNAs; mitochondria; metabolism; cancer; therapy; resistance; REGULATING HEXOKINASE 2; BLADDER-CANCER; TUMOR-GROWTH; GLUTAMINE-METABOLISM; COMPLEX I; PROLIFERATION; GLYCOLYSIS; TARGETS; GENOME; CELLS;

D O I：

10.3389/fgene.2024.1364389

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Non-coding ribonucleic acids (ncRNAs) have been recently shown to contribute to tumorigenesis by mediating changes in metabolism. ncRNAs act as key molecules in metabolic pathways regulation. The dysregulation of ncRNAs during cancer progression contributes to altered metabolic phenotypes leading to reprogrammed metabolism. Since ncRNAs affect different tumor processes by regulating mitochondrial dynamics and metabolism, in the future ncRNAs can be exploited in disease detection, diagnosis, treatment, and resistance. The purpose of this review is to highlight the role of ncRNAs in mitochondrial metabolic reprogramming and to relate their therapeutic potential in the management of genitourinary cancer.

引用

页数：13

共 129 条

[1] Hypoxia Regulates Endogenous Double-Stranded RNA Production via Reduced Mitochondrial DNA Transcription [J].

Arnaiz, Esther ;

Miar, Ana ;

Dias, Antonio Gregorio, Jr. ;

Prasad, Naveen ;

Schulze, Ulrike ;

Waithe, Dominic ;

Nathan, James A. ;

Rehwinkel, Jan ;

Harris, Adrian L. .

FRONTIERS IN ONCOLOGY, 2021, 11

[2] Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review [J].

Aveta, Achille ;

Cilio, Simone ;

Contieri, Roberto ;

Spena, Gianluca ;

Napolitano, Luigi ;

Manfredi, Celeste ;

Franco, Antonio ;

Crocerossa, Fabio ;

Cerrato, Clara ;

Ferro, Matteo ;

Del Giudice, Francesco ;

Verze, Paolo ;

Lasorsa, Francesco ;

Salonia, Andrea ;

Nair, Rajesh ;

Walz, Jochen ;

Lucarelli, Giuseppe ;

Pandolfo, Savio Domenico .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (13)

[3] Lincp21-RNA as Predictive Response Marker for Preoperative Chemoradiotherapy in Rectal Cancer [J].

Benitez, Jose Carlos ;

Campayo, Marc ;

Diaz, Tania ;

Ferrer, Carme ;

Acosta-Plasencia, Melissa ;

Monzo, Mariano ;

Cirera, Luis ;

Besse, Benjamin ;

Navarro, Alfons .

JOURNAL OF PERSONALIZED MEDICINE, 2021, 11 (05)

[4] Defining aggressive prostate cancer using a 12-gene model [J].

Bismar, Tarek A. ;

Demichelis, Francesca ;

Riva, Alberto ;

Kim, Robert ;

Varambally, Sooryanarayana ;

He, Le ;

Kutok, Jeff ;

Aster, Jonathan C. ;

Tang, Jeffery ;

Kuefer, Rainer ;

Hofer, Matthias D. ;

Febbo, Phillip G. ;

Chinnaiyan, Arul M. ;

Rubin, Mark A. .

NEOPLASIA, 2006, 8 (01) :59-68

[5] Targeting antisense mitochondrial noncoding RNAs induces bladder cancer cell death and inhibition of tumor growth through reduction of survival and invasion factors [J].

Borgna, Vincenzo ;

Lobos-Gonzalez, Lorena ;

Guevara, Francisca ;

Landerer, Eduardo ;

Bendek, Maximiliano ;

Avila, Rodolfo ;

Silva, Veronica ;

Villota, Claudio ;

Araya, Mariela ;

Rivas, Alexis ;

Lopez, Constanza ;

Socias, Teresa ;

Castillo, Jorge ;

Alarcon, Luis ;

Burzio, Luis O. ;

Burzio, Veronica A. ;

Villegas, Jaime .

JOURNAL OF CANCER, 2020, 11 (07) :1780-1791

[6] Mitochondrial ASncmtRNA-1 and ASncmtRNA-2 as potent targets to inhibit tumor growth and metastasis in the RenCa murine renal adenocarcinoma model [J].

Borgna, Vincenzo ;

Villegas, Jaime ;

Burzio, Veronica A. ;

Belmar, Sebastian ;

Araya, Mariela ;

Jeldes, Emanuel ;

Lobos-Gonzalez, Lorena ;

Silva, Veronica ;

Villota, Claudio ;

Oliveira-Cruz, Luciana ;

Lopez, Constanza ;

Socias, Teresa ;

Castillo, Octavio ;

Burzio, Luis O. .

ONCOTARGET, 2017, 8 (27) :43692-43708

[7] Endogenous miRNA and Target Concentrations Determine Susceptibility to Potential ceRNA Competition [J].

Bosson, Andrew D. ;

Zamudio, Jesse R. ;

Sharp, Phillip A. .

MOLECULAR CELL, 2014, 56 (03) :347-359

[8] Non-Coding RNA-Dependent Regulation of Mitochondrial Dynamics in Cancer Pathophysiology [J].

Cantafio, Maria Eugenia Gallo ;

Torcasio, Roberta ;

Viglietto, Giuseppe ;

Amodio, Nicola .

NON-CODING RNA, 2023, 9 (01)

[9] Cancer Cell Metabolism: One Hallmark, Many Faces [J].

Cantor, Jason R. ;

Sabatini, David M. .

CANCER DISCOVERY, 2012, 2 (10) :881-898

[10] Mitochondrial heterogeneity in diseases [J].

Chen, Long ;

Zhou, Mengnan ;

Li, Hao ;

Liu, Delin ;

Liao, Peng ;

Zong, Yao ;

Zhang, Changqing ;

Zou, Weiguo ;

Gao, Junjie .

SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 8 (01)

← 1 2 3 4 5 6 7 8 9 10 →