The relationship between aquaporins and skin diseases

被引：7

作者：

Liu, Jiahao ^{[1
]}

Jin, Yingji ^{[2
]}

Wei, Qinqin ^{[1
]}

Hu, Yewei ^{[1
]}

Liu, Liu ^{[1
]}

Feng, Yiran ^{[3
]}

Jin, Yuji ^{[4
]}

Jiang, Yong ^{[1
]}

机构：

[1] Jilin Med Univ, Dept Lab Med, Jilin 132013, Jilin, Peoples R China

[2] Yanbian Univ Hosp, Dept Dermatol, Yanji 133000, Jilin, Peoples R China

[3] Jilin Med Univ, Dept publ Hlth, Jilin 132013, Jilin, Peoples R China

[4] Jilin Med Univ, Dept Basic Med, Jilin 132013, Jilin, Peoples R China

来源：

EUROPEAN JOURNAL OF DERMATOLOGY | 2023年 / 33卷 / 04期

关键词：

aquaporin; physiological function; dermatosis; mechanism; WATER CHANNEL; BARRIER FUNCTION; CELL MIGRATION; SWEAT GLAND; EXPRESSION; GLYCEROL; IMMUNOLOCALIZATION; PROLIFERATION; KERATINOCYTES; HYDRATION;

D O I：

10.1684/ejd.2023.4526

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Aquaporins (AQPs) are a family of transmembrane channel proteins that can rapidly transport water molecules. The main subtype expressed in the epidermis and dermis is AQP3. Studies have confirmed that AQPs exert certain physiological functions in the skin, such as the maintenance of normal shape, the regulation of body temperature, moisturization and hydration, anti-aging, damage repair and antigen presentation. The abnormal expression of AQPs in skin cells can lead to a variety of skin diseases. This review summarizes the relevance of AQPs in dermatophysiological and pathophysiological processes, highlighting their potential as new drug targets for the treatment of skin diseases.

引用

页码：350 / 359

页数：10

共 81 条

[1] Testicular AQP1 expression in a rat model of testicular Ischemiae-Reperfusion injury [J].

Ablimit, Abduxukur ;

Abdureyim, Zumrat ;

Yang, Pan ;

Azmat, Rozjan ;

Shan, Weibi ;

Yao, Qiaoling .

JOURNAL OF PEDIATRIC UROLOGY, 2021, 17 (02) :169.e1-169.e6

[2] Aquaporin 3 and E-Cadherin Expression in Perilesional Vitiligo Skin [J].

Bakry, Ola Ahmed ;

Hagag, Magda Mostafa ;

Kandil, Mona Abd El Halim ;

Shehata, Wafaa Ahmed .

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2016, 10 (12) :WC1-WC6

[3] On the definition, nomenclature and classification of water channel proteins (aquaporins and relatives) [J].

Benga, Gheorghe .

MOLECULAR ASPECTS OF MEDICINE, 2012, 33 (5-6) :514-517

[4] Vitiligo: A Review [J].

Bergqvist, Christina ;

Ezzedine, Khaled .

DERMATOLOGY, 2020, 236 (06) :571-592

[5] Atopic dermatitis: an expanding therapeutic pipeline for a complex disease [J].

Bieber, Thomas .

NATURE REVIEWS DRUG DISCOVERY, 2022, 21 (01) :21-40

[6] Aquaporin-3 in the epidermis: more than skin deep [J].

Bollag, Wendy B. ;

Aitkens, Lorry ;

White, Joseph ;

Hyndman, Kelly A. .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2020, 318 (06) :C1144-C1153

[7] Expression and function of aquaporins in human skin:: Is aquaporin-3 just a glycerol transporter? [J].

Boury-Jamot, M. ;

Sougrat, R. ;

Tailhardat, M. ;

Le Varlet, B. ;

Bonte, F. ;

Dumas, M. ;

Verbavatz, J. -M. .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2006, 1758 (08) :1034-1042

[8]

Boury-Jamot Mathieu, 2009, Handb Exp Pharmacol, P205, DOI 10.1007/978-3-540-79885-9_10

[9] Immunolocalization of aquaporin-5 expression in sweat gland cells from normal and anhidrotic horses [J].

Bovell, DL ;

Lindsay, SL ;

Corbett, AD ;

Steel, C .

VETERINARY DERMATOLOGY, 2006, 17 (01) :17-23

[10] AQP7 mediates post-menopausal lipogenesis in adipocytes through FSH-induced transcriptional crosstalk with AP-1 sites [J].

Chen, Luting ;

Chen, Huixi ;

Liu, Xinmei ;

Li, Jingyi ;

Gao, Qian ;

Shi, Shuai ;

Wang, Tingting ;

Ye, Xiaoqun ;

Lu, Yongchao ;

Zhang, Dan ;

Sheng, Jianzhong ;

Jin, Li ;

Huang, Hefeng .

REPRODUCTIVE BIOMEDICINE ONLINE, 2020, 41 (06) :1122-1132

← 1 2 3 4 5 6 7 8 9 →