Polysaccharides from Chinese herbal medicine: a review on the hepatoprotective and molecular mechanism

被引：24

作者：

Li, Jifeng ^{[1
]}

Guo, Haolin ^{[1
]}

Dong, Ying ^{[1
]}

Yuan, Shuo ^{[2
]}

Wei, Xiaotong ^{[1
]}

Zhang, Yuxin ^{[1
]}

Dong, Lu ^{[1
]}

Wang, Fei ^{[1
]}

Bai, Ting ^{[1
]}

Yong, Yang ^{[1
]}

机构：

[1] Dalian Univ, Dalian Key Lab Chron Dis Res Ctr, Dalian 116622, Peoples R China

[2] Yanbian Univ, Coll Pharm, Key Lab Nat Med Changbai Mt, Minist Educ, Yanji 133002, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2024年 / 22卷 / 01期

关键词：

KEY WORDS] Polysaccharides; Hepatoprotective; Chinese herbal medicine; Mechanism; INDUCED LIVER-INJURY; PORIA-COCOS POLYSACCHARIDES; DRUG-DELIVERY-SYSTEM; LYCIUM-BARBARUM; DENDROBIUM-OFFICINALE; GANODERMA-LUCIDUM; FATTY LIVER; BIOACTIVE POLYSACCHARIDES; CARBON-TETRACHLORIDE; SIGNALING PATHWAY;

D O I：

10.1016/S1875-5364(24)60558-3

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

[ABSTRACT] Polysaccharides, predominantly extracted from traditional Chinese medicinal herbs such as Lycium barbarum, Angelica sinensis, Astragalus membranaceus, Dendrobium officinale, Ganoderma lucidum, and Poria cocos, represent principal bioactive constituents extensively utilized in Chinese medicine. These compounds have demonstrated significant anti-inflammatory capabilities, especially anti-liver injury activities, while exhibiting minimal adverse effects. This review summarized recent studies to elucidate the hepatoprotective efficacy and underlying molecular mechanisms of these herbal polysaccharides. It underscored the role of these polysaccharides in regulating hepatic function, enhancing immunological responses, and improving antioxidant capacities, thus contributing to the attenuation of hepatocyte apoptosis and liver protection. Analyses of molecular pathways in these studies revealed the intricate and indispensable functions of traditional Chinese herbal polysaccharides in liver injury management. Therefore, this review provides a thorough examination of the hepatoprotective attributes and molecular mechanisms of these medicinal polysaccharides, thereby offering valuable insights for the advancement of polysaccharide-based therapeutic research and their potential clinical applications in liver disease treatment.

引用

页码：4 / 14

页数：11

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