An Overview of Biopolymers for Drug Delivery Applications

被引:33
作者
Opris, Ocsana [1 ]
Mormile, Cristina [1 ,2 ,3 ]
Lung, Ildiko [1 ]
Stegarescu, Adina [1 ]
Soran, Maria-Loredana [1 ]
Soran, Albert [4 ]
机构
[1] Natl Inst Res & Dev Isotop & Mol Technol, 67-103 Donat, Cluj Napoca 400293, Romania
[2] Univ Roma La Sapienza, Fac Chem, Ple Aldo Moro 5, I-00185 Rome, Italy
[3] INFN Natl Labs Frascati, Via Enrico Fermi 54, I-00044 Frascati, Italy
[4] Babes Bolyai Univ, Fac Chem & Chem Engn, Supramol Organ & Organometall Chem Ctr SOOMCC, Dept Chem, 11 Arany Janos, 400028 Cluj Napoca, Romania
来源
APPLIED SCIENCES-BASEL | 2024年 / 14卷 / 04期
关键词
biopolymer; drug delivery; biomedical application; controlled release; materials; BOVINE SERUM-ALBUMIN; WAXY MAIZE STARCH; CONTROLLED-RELEASE; HYALURONIC-ACID; PHYSICOCHEMICAL CHARACTERIZATION; ALGINATE NANOPARTICLES; CHEMICAL-MODIFICATIONS; ELECTROSPUN FIBERS; MOLECULAR-WEIGHT; GENE-EXPRESSION;
D O I
10.3390/app14041383
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Nowadays, drug delivery has an important role in medical therapy. The use of biopolymers in developing drug delivery systems (DDSs) is increasingly attracting attention due to their remarkable and numerous advantages, in contrast to conventional polymers. Biopolymers have many advantages (biodegradability, biocompatibility, renewability, affordability, and availability), which are extremely important for developing materials with applications in the biomedical field. Additionally, biopolymers are appropriate when they improve functioning and have a number of positive effects on human life. Therefore, this review presents the most used biopolymers for biomedical applications, especially in drug delivery. In addition, by combining different biopolymers DDSs with tailored functional properties (e.g., physical properties, biodegradability) can be developed. This review summarizes and provides data on the progress of research on biopolymers (chitosan, alginate, starch, cellulose, albumin, silk fibroin, collagen, and gelatin) used in DDSs, their preparation, and mechanism of action.
引用
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页数:23
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