Inhibition of NOTCH4 Sensitizes FLT3/ITD Acute Myeloid Leukemia Cells to FLT3 Tyrosine Kinase Inhibition

被引：0

作者：

Zhu, Ruiqi ^{[1
]}

Shirley, Courtney ^{[2
]}

Chu, Haihua ^{[3
]}

Li, Li ^{[4
]}

Bao Nguyen ^{[5
]}

Seo, Jaesung ^{[2
]}

Seale, Tessa ^{[5
]}

Duffield, Amy ^{[6
]}

Staudt, Louis M. ^{[7
]}

Levis, Mark J. ^{[8
]}

Hu, Yu ^{[1
]}

Small, Donald ^{[5
]}

机构：

[1] Huazhong Univ Sci & Technol, Inst Hematol, Union Hosp, Tongji Med Coll, Wuhan, Peoples R China

[2] Johns Hopkins Univ, Baltimore, MD USA

[3] Beam Therapeut, Cambridge, MA USA

[4] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[5] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD USA

[6] Mt Sinai, New York, NY USA

[7] NCI, Lymphoid Malignancies Branch, Ctr Canc Res, NIH, Bethesda, MD USA

[8] Johns Hopkins Univ, Div Hematol Malignancies, Baltimore, MD USA

来源：

BLOOD | 2023年 / 142卷

关键词：

D O I：

10.1182/blood-2023-190696

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页数：3

共 50 条

[1] Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid leukemia cells to FLT3 tyrosine kinase inhibition
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[2] Genetic and Pharmacologic Notch4 Inhibition Synergizes with FLT3 Tyrosine Kinase Inhibition in Vitro to More Effectively Eliminate FLT3/ITD-Positive Leukemia Cells
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