Improving Polygenic Risk Scores for Coronary Artery Disease What Helps and by How Much?

被引：0
作者：
Ajufo, Ezimamaka C. [1 ,2 ]
Aragam, Krishna G. [2 ,3 ,4 ]
机构：
[1] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA USA
[2] MIT & Harvard, Broad Inst, Cambridge, MA USA
[3] Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA USA
[4] Massachusetts Gen Hosp, 185 Cambridge St,Simches Res Bldg 3-128, Boston, MA 02114 USA
来源：
JACC-BASIC TO TRANSLATIONAL SCIENCE | 2023年 / 8卷 / 12期
关键词：
biomarkers; coronary heart disease; FinnGen; genome-wide association studies; polygenic risk scores; PREDICTION;
D O I：
10.1016/j.jacbts.2023.10.005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：1580 / 1582
页数：3
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  • [1] Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
    Aragam, Krishna G.
    Jiang, Tao
    Goel, Anuj
    Kanoni, Stavroula
    Wolford, Brooke N.
    Atri, Deepak S.
    Weeks, Elle M.
    Wang, Minxian
    Hindy, George
    Zhou, Wei
    Grace, Christopher
    Roselli, Carolina
    Marston, Nicholas A.
    Kamanu, Frederick K.
    Surakka, Ida
    Venegas, Loreto Munoz
    Sherliker, Paul
    Koyama, Satoshi
    Ishigaki, Kazuyoshi
    Asvold, Bjorn O.
    Brown, Michael R.
    Brumpton, Ben
    de Vries, Paul S.
    Giannakopoulou, Olga
    Giardoglou, Panagiota
    Gudbjartsson, Daniel F.
    Gueldener, Ulrich
    Haider, Syed M. Ijlal
    Helgadottir, Anna
    Ibrahim, Maysson
    Kastrati, Adnan
    Kessler, Thorsten
    Kyriakou, Theodosios
    Konopka, Tomasz
    Li, Ling
    Ma, Lijiang
    Meitinger, Thomas
    Mucha, Soeren
    Munz, Matthias
    Murgia, Federico
    Nielsen, Jonas B.
    Noethen, Markus M.
    Pang, Shichao
    Reinberger, Tobias
    Schnitzler, Gavin
    Smedley, Damian
    Thorleifsson, Gudmar
    von Scheidt, Moritz
    Ulirsch, Jacob C.
    Arnar, David O.
    [J]. NATURE GENETICS, 2022, 54 (12) : 1803 - 1815
  • [2] Aragam KG, 2020, J AM COLL CARDIOL, V75, P2769, DOI 10.1016/j.jacc.2020.04.027
  • [3] Predictive Accuracy of a Polygenic Risk Score-Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease
    Elliott, Joshua
    Bodinier, Barbara
    Bond, Tom A.
    Chadeau-Hyam, Marc
    Evangelou, Evangelos
    Moons, Karel G. M.
    Dehghan, Abbas
    Muller, David C.
    Elliott, Paul
    Tzoulaki, Ioanna
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (07): : 636 - 645
  • [4] Integration of Biomarker Polygenic Risk Score Improves Prediction of Coronary Heart Disease
    Lin, Jake
    Mars, Nina
    Fu, Yu
    Ripatti, Pietari
    Kiiskinen, Tuomo
    Tukiainen, Taru
    Ripatti, Samuli
    Pirinen, Matti
    [J]. JACC-BASIC TO TRANSLATIONAL SCIENCE, 2023, 8 (12): : 1489 - 1499
  • [5] A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease
    Patel, Aniruddh P.
    Wang, Minxian
    Ruan, Yunfeng
    Koyama, Satoshi
    Clarke, Shoa L.
    Yang, Xiong
    Tcheandjieu, Catherine
    Agrawal, Saaket
    Fahed, Akl C.
    Ellinor, Patrick T.
    Tsao, Philip
    Sun, Yan, V
    Cho, Kelly
    Wilson, Peter W. F. L.
    Assimes, Themistocles L.
    van Heel, David A.
    Butterworth, Adam S.
    Aragam, Krishna G.
    Natarajan, Pradeep
    Khera, Amit V.
    [J]. NATURE MEDICINE, 2023, 29 (07) : 1793 - +
  • [6] Pitfalls of predicting complex traits from SNPs
    Wray, Naomi R.
    Yang, Jian
    Hayes, Ben J.
    Price, Alkes L.
    Goddard, Michael E.
    Visscher, Peter M.
    [J]. NATURE REVIEWS GENETICS, 2013, 14 (07) : 507 - 515
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