Visible-light-promoted desulfonylative radical difluoroalkylation between difluoroenol silyl ethers and difluoroalkyl sulfones to construct functionalized aryltetrafluoroethane derivatives

被引：7

作者：

Mu, Miaomiao ^{[1
,2
]}

Zhu, Xiaolei ^{[1
,2
]}

Li, Jinshan ^{[3
]}

Sun, Manman ^{[1
,2
]}

Yang, Jianguo ^{[1
,2
]}

Huang, Guobo ^{[1
,2
]}

Wang, Lei ^{[1
,2
]}

Wang, Zhiming ^{[1
,2
]}

机构：

[1] Taizhou Univ, Adv Res Inst, Jiaojiang 318000, Zhejiang, Peoples R China

[2] Taizhou Univ, Sch Pharmaceut Sci, Jiaojiang 318000, Zhejiang, Peoples R China

[3] Hainan Univ, Sch Chem & Chem Engn, Hainan Prov Key Lab Fine Chem, Haikou 570228, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2024年 / 11卷 / 05期

关键词：

FLUORINATED SULFONES; NUCLEOPHILIC FLUORINATION; FLUOROALKYLATION; TETRAFLUOROETHYLENE; DIFLUOROMETHYLATION; REACTIVITY; SULFOXIDES; CHEMISTRY; ALCOHOLS; ACCESS;

D O I：

10.1039/d3qo01606d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A visible-light-promoted desulfonylative radical difluoroalkylation between difluoroenol silyl ethers and difluoroalkyl sulfones has been developed. This protocol features mild conditions, simple operation, short reaction time and broad substrate scope, providing an efficient approach for obtaining a series of functionalized aryltetrafluoroethane derivatives in moderate to good yields. In addition, various synthetic derivatization experiments have been carried out to illustrate the practicality of this methodology. A visible-light-promoted desulfonylative radical difluoroalkylation between difluoroenol silyl ethers and difluoroalkyl sulfones has been developed.

引用

页码：1444 / 1449

页数：6

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