Spatiotemporal manipulation metal-organic frameworks as oral drug delivery systems for precision medicine

被引：41

作者：

Wang, Zhao ^{[1
]}

Chen, Jiao ^{[1
]}

Gao, Renchi ^{[1
]}

Jiang, Lingxi ^{[2
,3
,4
]}

Zhang, Gonghao ^{[1
]}

Zhao, Yang ^{[1
]}

Miao, Yang-Bao ^{[1
]}

Shi, Yi ^{[2
,3
,4
]}

机构：

[1] Univ Elect Sci & Technol China, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Dept Haematol, Sch Med, 32,West Sect 2,First Ring Rd, Chengdu 610000, Peoples R China

[2] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Ctr Med Genet, Sichuan Prov Key Lab Human Dis Gene Study, Chengdu 610072, Sichuan, Peoples R China

[3] Chinese Acad Sci, Sichuan Translat Med Hosp, Inst Chengdu Biol, Nat Prod Res Ctr, Chengdu 610072, Sichuan, Peoples R China

[4] Chinese Acad Med Sci 2019RU026, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Res Unit Blindness Prevent, Chengdu 610072, Sichuan, Peoples R China

来源：

COORDINATION CHEMISTRY REVIEWS | 2024年 / 502卷

基金：

中国国家自然科学基金;

关键词：

Metal -organic frameworks; Drug delivery; Biomaterials; Precision medicine; Spatiotemporal manipulation; ONE-POT SYNTHESIS; NANOCOMPOSITE HYDROGEL BEADS; PH-RESPONSIVE RELEASE; PHOTODYNAMIC THERAPY; BIO-NANOCOMPOSITE; SENSING PLATFORM; MOF; NANOPARTICLES; BARRIER; BIOAVAILABILITY;

D O I：

10.1016/j.ccr.2023.215615

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Oral drug administration is the preferred method for delivering medications due to its safety, ease of ingestion, high patient compliance, absence of pain, and adaptability to a wide range of drugs. However, the low oral bioavailability of many drugs poses a significant challenge, limiting the effectiveness of oral drug delivery. This comprehensive review presents recent advances in the rational design of metal-organic frameworks (MOFs) to improve oral drug delivery, along with the associated challenges and opportunities. The review provides an overview of different types of MOFs, synthesis methods, and various strategies for carrying and releasing drugs with spatiotemporal manipulation. The mechanisms behind these strategies utilizing MOFs spatiotemporal manipulation for precision medicine are discussed. Additionally, the review explores naturally sourced materials as potential new MOFs for oral delivery. Moreover, the review offers insights into the application of MOFs as oral drug delivery systems for precision medicine. By facilitating the development of customized MOFs nanoplatforms for specific diseases, this review aims to advance the field of precision medicine and enhance its practicality in oral drug delivery.

引用

页数：33

共 236 条

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