A dual role for adeno-associated virus in human health

被引：2

作者：

Araujo, Natalia M. ^{[1
]}

机构：

[1] Fiocruz MS, Oswaldo Cruz Inst, Lab Mol Virol & Parasitol, Rio De Janeiro, RJ, Brazil

来源：

VIROLOGY JOURNAL | 2023年 / 20卷 / 01期

关键词：

AAV; Hepatocellular carcinoma; Hepatitis; Children; Gene therapy;

D O I：

10.1186/s12985-023-02196-8

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Adeno-associated virus (AAV) differs from most other viruses, as it requires the simultaneous presence of a helper virus for an active infection. Up to 80% of the human population is seropositive for AAV antibodies. AAV has been known to be a non-pathogenic virus and an inhibitor of carcinogenesis caused by coinfecting viruses. However, the recent reports associating AAV infection with hepatocellular carcinoma development and the mysterious cases of acute severe hepatitis in children have challenged the idea that AAV is a harmless virus. Herein, we explore the usefulness of AAV in gene therapy and the importance of AAV as a protector or perpetrator in human carcinogenesis, ultimately reflecting on the dual role of AAV in human health.

引用

页数：3

共 32 条

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