Pain and its interference with daily living in relation to cancer: a comparative population-based study of 16,053 cancer survivors and 106,345 people without cancer

被引：11

作者：

Joshy, Grace ^{[1
]}

Khalatbari-Soltani, Saman ^{[2
]}

Soga, Kay ^{[1
]}

Butow, Phyllis ^{[3
]}

Laidsaar-Powell, Rebekah ^{[3
]}

Koczwara, Bogda ^{[4
,5
]}

Rankin, Nicole M. ^{[2
,6
]}

Brown, Sinan ^{[1
]}

Weber, Marianne ^{[7
]}

Mazariego, Carolyn ^{[8
]}

Grogan, Paul ^{[7
]}

Stubbs, John ^{[9
]}

Thottunkal, Stefan ^{[1
]}

Canfell, Karen ^{[7
]}

Blyth, Fiona M. ^{[2
]}

Banks, Emily ^{[1
]}

机构：

[1] Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth NCEPH, Canberra, ACT, Australia

[2] Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW, Australia

[3] Univ Sydney, Sch Psychol, Ctr Med Psychol & Evidence Based Decis Making CeMP, Sydney, NSW, Australia

[4] Flinders Univ S Australia, Flinders Hlth & Med Res Inst, Adelaide, SA, Australia

[5] Flinders Med Ctr, Dept Med Oncol, Adelaide, SA, Australia

[6] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia

[7] Univ Sydney Joint Venture Canc Council NSW, Daffodil Ctr, Sydney, NSW, Australia

[8] Univ New South Wales, Sch Populat Hlth, Sydney, NSW, Australia

[9] Independent Canc Consumer Advisor, Sydney, NSW, Australia

来源：

BMC CANCER | 2023年 / 23卷 / 01期

关键词：

Cancer; Pain; Pain interference; High-impact pain; Physical functioning; Psychological distress; Quality of life; PSYCHOLOGICAL DISTRESS; COHORT; SCALE; LIFE;

D O I：

10.1186/s12885-023-11214-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundPain is a common, debilitating, and feared symptom, including among cancer survivors. However, large-scale population-based evidence on pain and its impact in cancer survivors is limited. We quantified the prevalence of pain in community-dwelling people with and without cancer, and its relation to physical functioning, psychological distress, and quality of life (QoL).MethodsQuestionnaire data from participants in the 45 and Up Study (Wave 2, n = 122,398, 2012-2015, mean age = 60.8 years), an Australian population-based cohort study, were linked to cancer registration data to ascertain prior cancer diagnoses. Modified Poisson regression estimated age- and sex-adjusted prevalence ratios (PRs) for bodily pain and pain sufficient to interfere with daily activities (high-impact pain) in people with versus without cancer, for 13 cancer types, overall and according to clinical, personal, and health characteristics. The relation of high-impact pain to physical and mental health outcomes was quantified in people with and without cancer.ResultsOverall, 34.9% (5,436/15,570) of cancer survivors and 31.3% (32,471/103,604) of participants without cancer reported bodily pain (PR = 1.07 [95% CI = 1.05-1.10]), and 15.9% (2,468/15,550) versus 13.1% (13,573/103,623), respectively, reported high-impact pain (PR = 1.13 [1.09-1.18]). Pain was greater with more recent cancer diagnosis, more advanced disease, and recent cancer treatment. High-impact pain varied by cancer type; compared to cancer-free participants, PRs were: 2.23 (1.71-2.90) for multiple myeloma; 1.87 (1.53-2.29) for lung cancer; 1.06 (0.98-1.16) for breast cancer; 1.05 (0.94-1.17) for colorectal cancer; 1.04 (0.96-1.13) for prostate cancer; and 1.02 (0.92-1.12) for melanoma. Regardless of cancer diagnosis, high-impact pain was strongly related to impaired physical functioning, psychological distress, and reduced QoL.ConclusionsPain is common, interfering with daily life in around one-in-eight older community-dwelling participants. Pain was elevated overall in cancer survivors, particularly for certain cancer types, around diagnosis and treatment, and with advanced disease. However, pain was comparable to population levels for many common cancers, including breast, prostate and colorectal cancer, and melanoma.

引用

页数：11

共 35 条

[31]

Stewart AL., 1992, Measuring functioning and well-being, P86

[32] Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J].