Research Progress of Plant Active Ingredients in Pharmaceutical Cocrystal

被引：3

作者：

Wang, Zimeng ^{[1
]}

Shang, Hongzhou ^{[2
]}

Gao, Linghuan ^{[3
]}

Qiao, Ning ^{[2
]}

机构：

[1] North China Univ Sci & Technol, Coll Pharm, Tangshan 063210, Peoples R China

[2] North China Univ Sci & Technol, Coll Mat Sci & Engn, Tangshan 063210, Peoples R China

[3] North China Univ Sci & Technol, Coll Basic Med Sci, Tangshan 063210, Peoples R China

来源：

CURRENT DRUG DELIVERY | 2023年 / 20卷 / 10期

关键词：

Herbal ingredients; pharmaceutical cocrystals; properties solubility; bioavailability; medicinal; API's; ORAL BIOAVAILABILITY; CRYSTAL-STRUCTURES; SOLUBILITY; MYRICETIN; ARTEMISININ; KAEMPFEROL; INSIGHTS; DESIGN; ACIDS;

D O I：

10.2174/1567201819666220820115950

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The disadvantages of active ingredients extracted from medicinal plants due to poor solubility in the body and low bioavailability limit their clinical application. Pharmaceutical cocrystal as a new type of drug in solid form has attracted the attention of researchers. This article reviews the effects of cocrystal in various poorly soluble herbal active ingredients of medicinal plants on their physicochemical properties and biological properties and provides references for the application of pharmaceutical cocrystal in poorly soluble active compounds of medicinal plants.

引用

页码：1405 / 1424

页数：20

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