Inflammaging: mechanisms and role in the cardiac and vasculature

被引：26

作者：

Ajoolabady, Amir ^{[1
]}

Pratico, Domenico ^{[2
]}

Vinciguerra, Manlio ^{[3
]}

Lip, Gregory Y. H. ^{[4
,5
,6
]}

Franceschi, Claudio ^{[7
,8
,9
]}

Ren, Jun ^{[1
,10
]}

机构：

[1] Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Dept Cardiol, Shanghai 200032, Peoples R China

[2] Temple Univ, Alzheimers Ctr Temple, Lewis Katz Sch Med, Philadelphia, PA 19140 USA

[3] Liverpool Johns Moore Univ, Liverpool Ctr Cardiovasc Sci, Liverpool, England

[4] Univ Liverpool, Liverpool Ctr Cardiovasc Sci, Liverpool, England

[5] Liverpool Heart & Chest Hosp, Liverpool, England

[6] Aalborg Univ, Dept Clin Med, Aalborg, Denmark

[7] Ist Ricovero & Cura Carattere Sci IRCCS, Inst Neurol Sci Bologna, Bologna, Italy

[8] Lobachevsky Univ, Dept Appl Math, Nizhnii Novgorod, Russia

[9] Lobachevsky Univ, Lab Syst Biol Aging, Nizhnii Novgorod, Russia

[10] Univ Washington, Dept Lab Med & Pathol, Seattle, WA 98195 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2023年 / 34卷 / 06期

关键词：

CARDIOVASCULAR-DISEASE ENTERPRISES; ENDOTHELIAL-CELL SENESCENCE; ANGIOTENSIN-II; NLRP3; INFLAMMASOME; MATRIX METALLOPROTEINASES; UP-REGULATION; MAJOR SHAREHOLDERS; HUMAN LONGEVITY; HEART-FAILURE; IMMUNE-SYSTEM;

D O I：

10.1016/j.tem.2023.03.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aging triggers a wide range of cellular and molecular aberrations in the body, giving rise to inflammation and associated diseases. In particular, aging is associated with persistent low-grade inflammation even in absence of inflammatory stimuli, a phenomenon commonly referred to as 'inflammaging'. Accumulating evidence has revealed that inflammaging in vascular and cardiac tissues is associated with the emergence of pathological states such as atherosclerosis and hyperten-sion. In this review we survey molecular and pathological mechanisms of inflammaging in vascular and cardiac aging to identify potential targets, natural therapeutic compounds, and other strategies to suppress inflammaging in the heart and vasculature, as well as in associated diseases such as atherosclerosis and hypertension.

引用

页码：373 / 387

页数：15

共 121 条

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