Guanidine Hydrochloride Catalyzed One-Pot Multi-Component Synthesis of Pyrazolopyranopyrimidine

被引：5

作者：

Barkule, Angad B. ^{[1
]}

Gadkari, Yatin U. ^{[2
]}

Salim, Simren S. ^{[1
]}

Lomte, Savita B. ^{[1
]}

Telvekar, Vikas N. ^{[1
]}

机构：

[1] Inst Chem Technol, Dept Pharmaceut Sci & Technol, Mumbai 400019, India

[2] Inst Chem Technol Indian Oil, Dept Pharmaceut Sci & Technol, Odisha Campus, Bhubaneswar 751013, India

来源：

CHEMISTRYSELECT | 2023年 / 8卷 / 21期

关键词：

Aqueous condition; guanidine hydrochloride; multi-component reaction; pyrazolopyranopyrimidine; recyclability; 4-COMPONENT SYNTHESIS; EFFICIENT CATALYST; GREEN; DERIVATIVES; ORGANOCATALYST; PROTOCOL; DESIGN;

D O I：

10.1002/slct.202300990

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An expeditious and highly efficient methodology for the synthesis of pyrazolopyranopyrimidine under aqueous conditions is reported using guanidine hydrochloride as a catalyst. One-pot multicomponent synthesis from aryl/heterocyclic aldehyde, ethyl acetoacetate, barbituric acid, and hydrazine hydrate to give the final compound in moderate to excellent yield. The recyclability (up to 4 cycles), safe, low cost, and wide stability profile of guanidine hydrochloride fulfil the ideal properties of the catalyst. The current protocol shows several advantages such as its environmentally benign nature, shorter reaction time, high yield, simple work-up procedure, broad substrate tolerance, absence of hazardous organic solvent, etc.

引用

页数：6

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