Baicalein Attenuates Brain Iron Accumulation through Protecting Aconitase 1 from Oxidative Stress in Rotenone-Induced Parkinson's Disease in Rats

被引：16

作者：

Liu, Run-Zhe ^{[1
,2
]}

Zhang, Sen ^{[1
,2
]}

Zhang, Wen ^{[1
,2
]}

Zhao, Xiao-Yue ^{[1
,2
,3
]}

Du, Guan-Hua ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Drug Target Identificat & Drug Scr, Beijing 100050, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Med Sci Res Ctr, Beijing 100730, Peoples R China

来源：

ANTIOXIDANTS | 2023年 / 12卷 / 01期

基金：

国家重点研发计划;

关键词：

baicalein; Aconitase 1 (ACO1); iron regulatory protein 1 (IRP1); Parkinson's disease; iron accumulation; MITOCHONDRIAL COMPLEX I; UP-REGULATION; MODEL; COENZYME-Q10; INHIBITION; ACTIVATION; EXPRESSION; DOPAMINE; MICE;

D O I：

10.3390/antiox12010012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aconitase 1 (ACO1) links oxidative stress and iron accumulation in Parkinson's disease (PD). ACO1 loses its aconitase activity and turns into iron regulatory protein 1 (IRP1) upon oxidative stress. IRP1 plays an important role in the accumulation of intracellular iron. Baicalein is a flavonoid isolated from the roots of Scutellaria baicalensis. The present results show that baicalein could bind to ACO1 and protect its isoform from the oxidative stress induced by reactive oxygen species (ROS) and reactive nitrogen species (RNS). Furthermore, baicalein promoted aconitase activity and inhibited IRP1 activation in rotenone-induced PD models. Additionally, baicalein decreased the hydroxyl radicals generated by iron. In conclusion, baicalein attenuated iron accumulation and iron-induced oxidative stress in the brain of PD rats by protecting ACO1.

引用

页数：13

共 58 条

[1] Parkinson disease-associated cognitive impairment [J].

Aarsland, Dag ;

Batzu, Lucia ;

Halliday, Glenda M. ;

Geurtsen, Gert J. ;

Ballard, Clive ;

Chaudhuri, K. Ray ;

Weintraub, Daniel .

NATURE REVIEWS DISEASE PRIMERS, 2021, 7 (01)

[2] Mechanism of the neuroprotective role of coenzyme Q10 with or without L-dopa in rotenone-induced parkinsonism [J].

Abdin, Amany A. ;

Hamouda, Hala E. .

NEUROPHARMACOLOGY, 2008, 55 (08) :1340-1346

[3] The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1 [J].

Aguirre, Pabla ;

Urrutia, Pamela ;

Tapia, Victoria ;

Villa, Monica ;

Paris, Irmgad ;

Segura-Aguilar, Juan ;

Nunez, Marco T. .

BIOMETALS, 2012, 25 (04) :795-803

[4] Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged [J].

Beal, MF ;

Matthews, RT ;

Tieleman, A ;

Shults, CW .

BRAIN RESEARCH, 1998, 783 (01) :109-114

[5] The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis [J].

Bersuker, Kirill ;

Hendricks, Joseph M. ;

Li, Zhipeng ;

Magtanong, Leslie ;

Ford, Breanna ;

Tang, Peter H. ;

Roberts, Melissa A. ;

Tong, Bingqi ;

Maimone, Thomas J. ;

Zoncu, Roberto ;

Bassik, Michael C. ;

Nomura, Daniel K. ;

Dixon, Scott J. ;

Olzmann, James A. .

NATURE, 2019, 575 (7784) :688-+

[6] Endocytic iron trafficking and mitochondria in Parkinson's disease [J].

Cerri, Silvia ;

Milanese, Chiara ;

Mastroberardino, Pier G. .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2019, 110 :70-74

[7] Interactions between iron and α-synuclein pathology in Parkinson's disease [J].

Chen, Bingbing ;

Wen, Xiaoming ;

Jiang, Hong ;

Wang, Jun ;

Song, Ning ;

Xie, Junxi .

FREE RADICAL BIOLOGY AND MEDICINE, 2019, 141 :253-260

[8] Neuroprotective effect of baicalein against MPTP neurotoxicity: Behavioral, biochemical and immunohistochemical profile [J].

Cheng, Yinxia ;

He, Guorong ;

Mu, Xin ;

Zhang, Tiantai ;

Li, Xiaoxiu ;

Hu, Juanjuan ;

Xu, Bei ;

Du, Guanhua .

NEUROSCIENCE LETTERS, 2008, 441 (01) :16-20

[9] Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease [J].

Devos, David ;

Moreau, Caroline ;

Devedjian, Jean Christophe ;

Kluza, Jerome ;

Petrault, Maud ;

Laloux, Charlotte ;

Jonneaux, Aurelie ;

Ryckewaert, Gilles ;

Garcon, Guillaume ;

Rouaix, Nathalie ;

Duhamel, Alain ;

Jissendi, Patrice ;

Dujardin, Kathy ;

Auger, Florent ;

Ravasi, Laura ;

Hopes, Lucie ;

Grolez, Guillaume ;

Firdaus, Wance ;

Sablonniere, Bernard ;

Strubi-Vuillaume, Isabelle ;

Zahr, Noel ;

Destee, Alain ;

Corvol, Jean-Christophe ;

Poeltl, Dominik ;

Leist, Marcel ;

Rose, Christian ;

Defebvre, Luc ;

Marchetti, Philippe ;

Cabantchik, Z. Ioav ;

Bordet, Regis .

ANTIOXIDANTS & REDOX SIGNALING, 2014, 21 (02) :195-210

[10] INCREASED NIGRAL IRON CONTENT AND ALTERATIONS IN OTHER METAL-IONS OCCURRING IN BRAIN IN PARKINSONS-DISEASE [J].

DEXTER, DT ;

WELLS, FR ;

LEES, AJ ;

AGID, F ;

AGID, Y ;

JENNER, P ;

MARSDEN, CD .

JOURNAL OF NEUROCHEMISTRY, 1989, 52 (06) :1830-1836

← 1 2 3 4 5 6 →