Oncogenic lesions and molecular subtypes in adults with B-cell acute lymphoblastic leukemia

被引：5

作者：

Yasuda, Takahiko ^{[1
]}

Sanada, Masashi ^{[1
]}

Tsuzuki, Shinobu ^{[2
]}

Hayakawa, Fumihiko ^{[3
]}

机构：

[1] Natl Hosp Org, Clin Res Ctr, Nagoya Med Ctr, Nagoya, Aichi, Japan

[2] Aichi Med Univ, Dept Biochem, Sch Med, Nagakute, Aichi, Japan

[3] Nagoya Univ, Dept Integrated Hlth Sci, Div Cellular & Genet Sci, Grad Sch Med, Nagoya, Aichi, Japan

来源：

CANCER SCIENCE | 2023年 / 114卷 / 01期

关键词：

acute lymphoblastic leukemia; adult; gene rearrangement; prognosis; RNA-seq; GENE FUSION; DUX4; CLASSIFICATION; IDENTIFICATION; DEFINE; MUTATIONS;

D O I：

10.1111/cas.15583

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

B-cell acute lymphoblastic leukemia (B-ALL), a genetically heterogeneous disease, is classified into different molecular subtypes that are defined by recurrent gene rearrangements, gross chromosomal abnormalities, or specific gene mutations. Cells with these genetic alterations acquire a leukemia-initiating ability and show unique expression profiles. The distribution of B-ALL molecular subtypes is greatly dependent on age, which also affects treatment responsiveness and long-term survival, partly accounting for the inferior outcome in adolescents and young adults (AYA) and (older) adults with B-ALL. Recent advances in sequencing technology, especially RNA sequencing and the application of these technologies in large B-ALL cohorts have uncovered B-ALL molecular subtypes prevalent in AYA and adults. These new insights supply more precise estimations of prognoses and targeted therapies informed by sequencing results, as well as a deeper understanding of the genetic basis of AYA/adult B-ALL. This article provides an account of these technological advances and an overview of the recent major findings of B-ALL molecular subtypes in adults.

引用

页码：8 / 15

页数：8

共 61 条

[1] The genetic basis and cell of origin of mixed phenotype acute leukaemia [J].

Alexander, Thomas B. ;

Gu, Zhaohui ;

Iacobucci, Ilaria ;

Dickerson, Kirsten ;

Choi, John K. ;

Xu, Beisi ;

Payne-Turner, Debbie ;

Yoshihara, Hiroki ;

Loh, Mignon L. ;

Horan, John ;

Buldini, Barbara ;

Basso, Giuseppe ;

Elitzur, Sarah ;

de Haas, Valerie ;

Zwaan, C. Michel ;

Yeoh, Allen ;

Reinhardt, Dirk ;

Tomizawa, Daisuke ;

Kiyokawa, Nobutaka ;

Lammens, Tim ;

De Moerloose, Barbara ;

Catchpoole, Daniel ;

Hori, Hiroki ;

Moorman, Anthony ;

Moore, Andrew S. ;

Hrusak, Ondrej ;

Meshinchi, Soheil ;

Orgel, Etan ;

Devidas, Meenakshi ;

Borowitz, Michael ;

Wood, Brent ;

Heerema, Nyla A. ;

Carrol, Andrew ;

Yang, Yung-Li ;

Smith, Malcolm A. ;

Davidsen, Tanja M. ;

Hermida, Leandro C. ;

Gesuwan, Patee ;

Marra, Marco A. ;

Ma, Yussanne ;

Mungall, Andrew J. ;

Moore, Richard A. ;

Jones, Steven J. M. ;

Valentine, Marcus ;

Janke, Laura J. ;

Rubnitz, Jeffrey E. ;

Pui, Ching-Hon ;

Ding, Liang ;

Liu, Yu ;

Zhang, Jinghui .

NATURE, 2018, 562 (7727) :373-+

[2] IDH1 and IDH2 mutations in pediatric acute leukemia [J].

Andersson, A. K. ;

Miller, D. W. ;

Lynch, J. A. ;

Lemoff, A. S. ;

Cai, Z. ;

Pounds, S. B. ;

Radtke, I. ;

Yan, B. ;

Schuetz, J. D. ;

Rubnitz, J. E. ;

Ribeiro, R. C. ;

Raimondi, S. C. ;

Zhang, J. ;

Mullighan, C. G. ;

Shurtleff, S. A. ;

Schulman, B. A. ;

Downing, J. R. .

LEUKEMIA, 2011, 25 (10) :1570-1577

[3] The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia [J].

Arber, Daniel A. ;

Orazi, Attilio ;

Hasserjian, Robert ;

Thiele, Jurgen ;

Borowitz, Michael J. ;

Le Beau, Michelle M. ;

Bloomfield, Clara D. ;

Cazzola, Mario ;

Vardiman, James W. .

BLOOD, 2016, 127 (20) :2391-2405

[4] RNAseqCNV: analysis of large-scale copy number variations from RNA-seq data [J].

Barinka, Jan ;

Hu, Zunsong ;

Wang, Lu ;

Wheeler, David A. ;

Rahbarinia, Delaram ;

McLeod, Clay ;

Gu, Zhaohui ;

Mullighan, Charles G. .

LEUKEMIA, 2022, 36 (06) :1492-1498

[5] UBTF::ATXN7L3 gene fusion defines novel B cell precursor ALL subtype with CDX2 expression and need for intensified treatment [J].

Bastian, Lorenz ;

Hartmann, Alina M. ;

Beder, Thomas ;

Haenzelmann, Sonja ;

Kaessens, Jan ;

Bultmann, Miriam ;

Hoeppner, Marc P. ;

Franzenburg, Soeren ;

Wittig, Michael ;

Franke, Andre ;

Nagel, Inga ;

Spielmann, Malte ;

Reimer, Niklas ;

Busch, Hauke ;

Schwartz, Stefan ;

Steffen, Bjoern ;

Viardot, Andreas ;

Doehner, Konstanze ;

Kondakci, Mustafa ;

Wulf, Gerald ;

Wendelin, Knut ;

Renzelmann, Andrea ;

Kiani, Alexander ;

Trautmann, Heiko ;

Neumann, Martin ;

Goekbuget, Nicola ;

Brueggemann, Monika ;

Baldus, Claudia D. .

LEUKEMIA, 2022, 36 (06) :1676-1680

[6] Evolutionary trajectories of hyperdiploid ALL in monozygotic twins [J].

Bateman, C. M. ;

Alpar, D. ;

Ford, A. M. ;

Colman, S. M. ;

Wren, D. ;

Morgan, M. ;

Kearney, L. ;

Greaves, M. .

LEUKEMIA, 2015, 29 (01) :58-65

[7] Natural history and cell of origin of TCF3-ZNF384 and PTPN11 mutations in monozygotic twins with concordant BCP-ALL [J].

Bueno, Clara ;

Ramon Tejedor, J. ;

Bashford-Rogers, Rachael ;

Gonzalez-Silva, Laura ;

Valdes-Mas, Rafael ;

Agraz-Doblas, Antonio ;

Diaz de la Guardia, Rafael ;

Ribera, Jordi ;

Zamora, Lurdes ;

Bilhou-Nabera, Chrystele ;

Abermil, Nassera ;

Guermouche, Helene ;

Gouache, Elodie ;

Leverger, Guy ;

Fraga, Mario F. ;

Fernandez, Agustin F. ;

Ballerini, Paola ;

Varela, Ignacio ;

Menendez, Pablo .

BLOOD, 2019, 134 (11) :900-905

[8] ZNF384 Fusion Oncoproteins Drive Lineage Aberrancy in Acute Leukemia [J].

Dickerson, Kirsten M. ;

Qu, Chunxu ;

Gao, Qingsong ;

Iacobucci, Ilaria ;

Gu, Zhaohui ;

Yoshihara, Hiroki ;

Backhaus, Emily A. ;

Chang, Yunchao ;

Janke, Laura J. ;

Xu, Beisi ;

Wu, Gang ;

Papachristou, Evangelia K. ;

D'Santos, Clive S. ;

Roberts, Kathryn G. ;

Mullighan, Charles G. .

BLOOD CANCER DISCOVERY, 2022, 3 (03) :240-263

[9] Backtracking leukemia to birth: Identification of clonotypic gene fusion sequences in neonatal blood spots [J].

Gale, KB ;

Ford, AM ;

Repp, R ;

Borkhardt, A ;

Keller, C ;

Eden, OB ;

Greaves, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (25) :13950-13954

[10] A novel recurrent EP300-ZNF384 gene fusion in B-cell precursor acute lymphoblastic leukemia [J].

Gocho, Y. ;

Kiyokawa, N. ;

Ichikawa, H. ;

Nakabayashi, K. ;

Osumi, T. ;

Ishibashi, T. ;

Ueno, H. ;

Terada, K. ;

Oboki, K. ;

Sakamoto, H. ;

Shioda, Y. ;

Imai, M. ;

Noguchi, Y. ;

Arakawa, Y. ;

Kojima, Y. ;

Toyama, D. ;

Hata, K. ;

Yoshida, T. ;

Matsumoto, K. ;

Kato, M. ;

Fukushima, T. ;

Koh, K. ;

Manabe, A. ;

Ohara, A. .

LEUKEMIA, 2015, 29 (12) :2445-2448

← 1 2 3 4 5 6 7 →