Decorrelated compounding of synthetic aperture ultrasound imaging to detect low contrast thermal lesions induced by focused ultrasound

Purpose: Decorrelated Compounding (DC) for synthetic aperture ultrasound can reduce speckle variation in images, suggesting enhanced detectability of low-contrast targets in tissue including thermal lesions produced by focused ultrasound (FUS). The DC imaging method has primarily been investigated in simulation and in phantom studies. This work investigates the feasibility of the DC method in monitoring thermal therapy via image guidance and non-invasive thermometry based on the change in backscattered energy (CBE).Methods: Ex vivo porcine tissue was exposed to FUS exposures at acoustic powers of 5 W and 1 W, with peak pressure amplitudes of 0.64 MPa and 0.27 MPa respectively. During FUS exposure, RF echo data frames was acquired using a 7.8 MHz linear array probe and a Verasonics VantageTM ultrasound scanner (Verasonics Inc., Redmond, WA). RF echo data was taken to produce B-mode images, as reference images. Synthetic aperture RF echo data was also acquired and processed using delay-and-sum (DAS), a combination of spatial and frequency compounding referred to as Traditional Compounding (TC), and the proposed DC imaging methods. Image quality was assessed using the contrast-to-noise ratio (CNR) at the FUS beam focus, and the speckle SNR (sSNR) of the background region as preliminary metrics. A calibrated thermocouple was placed near the FUS beam focus for temperature measurements and calibrations using the CBE method.Results: The DC imaging method significantly improved image quality to detect low contrast thermal lesions in treated ex vivo porcine tissue in comparison to other imaging methods. In comparison to B-mode imaging, the lesion CNR measured using the DC imaging was shown to improve up to a factor of approximately 5.5. The corresponding sSNR improved by a factor of approximately 4.2 in comparison to B-mode imaging. CBE calcu-lation using the DC imaging method yielded more precise measurements of the backscattered energy compared to other imaging methods studied.Conclusions: The despeckling performance of the DC imaging method significantly improves the lesion CNR in comparison to B-mode imaging. This suggests that the proposed method can detect low-contrast thermal lesions induced by FUS therapy that are not detectable using standard B-mode imaging. Furthermore, the signal change at the focal point were more precisely measured by DC imaging, and the signal change in response to FUS exposure follows the temperature profile more closely than changes measured using B-mode, as well as synthetic aperture DAS and TC images. These suggest that DC imaging can potentially be used with the CBE method to improve non-invasive thermometry.