Transcriptomic insights into adenoid cystic carcinoma via RNA sequencing

被引:4
|
作者
Tang, Yu-Fang [1 ,2 ,3 ,4 ,5 ]
An, Pu-Gen [1 ,2 ,3 ,4 ]
Gu, Bao-Xin [1 ,2 ,3 ,4 ]
Yi, Shu [1 ,2 ,3 ,4 ]
Hu, Xiao [1 ,2 ,3 ,4 ]
Wu, Wen-Jie [1 ,2 ,3 ,4 ]
Zhang, Jie [1 ,2 ,3 ,4 ]
机构
[1] Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing, Peoples R China
[2] Natl Ctr Stomatol, Beijing, Peoples R China
[3] Natl Clin Res Ctr Oral Dis, Beijing, Peoples R China
[4] Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing, Peoples R China
[5] Army Med Univ, Xinqiao Hosp, Affiliated Hosp 2, Dept Stomatol, Chongqing, Peoples R China
关键词
adenoid cystic carcinoma (ACC); RNA sequencing; gene fusions; cancer germline antigens; mRNA; CLASS-I ANTIGEN; DOWN-REGULATION; PROGNOSTIC-FACTORS; POOR-PROGNOSIS; GENE FUSIONS; TUMOR ESCAPE; EXPRESSION; CANCER; PRAME; HEAD;
D O I
10.3389/fgene.2023.1144945
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Background: The aim of this study was to investigate the underlying mechanisms of adenoid cystic carcinoma (ACC) at the transcriptome level.Materials and methods: We obtained paired tumor and normal salivary gland tissues from 15 ACC patients, which were prepared for RNA sequencing.Results: Gene enrichment analysis revealed that the upregulated pathways were mainly involved in axonogenesis, and the downregulated pathways were mainly related to leukocyte migration, the adaptive immune response, lymphocyte-mediated immunity, and the humoral immune response. T-cells, B-cells and NK cells showed low infiltration in ACC tissues. In addition to the gene fusions MYB-NFIB and MYBL1-NFIB, a new gene fusion, TVP23C-CDRT4, was also detected in 3 ACC tissues. PRAME was significantly upregulated in ACC tissues, while antigen-presenting human leukocyte antigen (HLA) genes were downregulated.Conclusion: We found a new gene fusion, TVP23C-CDRT4, that was highly expressed in ACC. PRAME may be an attractive target for ACC immunotherapy.
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页数:17
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