Invasive pulmonary aspergillosis in the intensive care unit: current challenges and best practices

被引：17

作者：

Gaffney, Sarah ^{[1
]}

Kelly, Dearbhla M. ^{[1
]}

Rameli, Puteri Maisarah ^{[1
]}

Kelleher, Eoin ^{[2
]}

Martin-Loeches, Ignacio ^{[1
,3
,4
,5
]}

机构：

[1] St James Hosp, Dept Intens Care Med, Multidisciplinary Intens Care Res Org MICRO, Dublin, Ireland

[2] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Oxford, England

[3] Trinity Coll Dublin, Sch Med, Dept Clin Med, Dublin, Ireland

[4] Univ Barcelona, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Hosp Clin, Barcelona, Spain

[5] St James Hosp, Dept Intens Care Med, Multidisciplinary Intens Care Res Org MICRO, Dublin D08 NHY1, Ireland

来源：

APMIS | 2023年 / 131卷 / 11期

关键词：

Invasive aspergillosis; fungal infection; antifungal therapy; BRONCHOALVEOLAR LAVAGE FLUID; LIPOSOMAL AMPHOTERICIN-B; CRITICALLY-ILL PATIENTS; FUNGAL-INFECTIONS; IMMUNOCOMPROMISED PATIENTS; ANTIFUNGAL THERAPY; ADULT PATIENTS; GALACTOMANNAN; DIAGNOSIS; POSACONAZOLE;

D O I：

10.1111/apm.13316

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The prevalence of invasive pulmonary aspergillosis (IPA) is growing in critically ill patients in the intensive care unit (ICU). It is increasingly recognized in immunocompetent hosts and immunocompromised ones. IPA frequently complicates both severe influenza and severe coronavirus disease 2019 (COVID-19) infection. It continues to represent both a diagnostic and therapeutic challenge and can be associated with significant morbidity and mortality. In this narrative review, we describe the epidemiology, risk factors and disease manifestations of IPA. We discuss the latest evidence and current published guidelines for the diagnosis and management of IPA in the context of the critically ill within the ICU. Finally, we review influenza-associated pulmonary aspergillosis (IAPA), COVID-19-associated pulmonary aspergillosis (CAPA) as well as ongoing and future areas of research.

引用

页码：654 / 667

页数：14

共 81 条

[1] The Effect of Chronic Infection With Aspergillus fumigatus on Lung Function and Hospitalization in Patients With Cystic Fibrosis [J].

Amin, Reshma ;

Dupuis, Annie ;

Aaron, Shawn D. ;

Ratjen, Felix .

CHEST, 2010, 137 (01) :171-176

[2]

[Anonymous], 2018, Health Protection Surveillance Centre

[3] Future Directions for Clinical Respiratory Fungal Research [J].

Armstrong-James, Darius .

MYCOPATHOLOGIA, 2021, 186 (05) :685-696

[4] False-positive Aspergillus galactomannan antigenaemia after haematopoietic stem cell transplantation [J].

Asano-Mori, Yuki ;

Kanda, Yoshinobu ;

Oshima, Kumi ;

Kako, Shinichi ;

Shinohara, Akihito ;

Nakasone, Hideki ;

Kaneko, Makoto ;

Sato, Hiroyuki ;

Watanabe, Takuro ;

Hosoya, Noriko ;

Izutsu, Koji ;

Asai, Takashi ;

Hangaishi, Akira ;

Motokura, Toru ;

Chiba, Shigeru ;

Kurokawa, Mineo .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2008, 61 (02) :411-416

[5] Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: An international consensus [J].

Ascioglu, S ;

Rex, JH ;

de Pauw, B ;

Bennett, JE ;

Bille, J ;

Crokaert, F ;

Denning, DW ;

Donnelly, JP ;

Edwards, JE ;

Erjavec, Z ;

Fiere, D ;

Lortholary, O ;

Maertens, J ;

Meis, JF ;

Patterson, TF ;

Ritter, J ;

Selleslag, D ;

Shah, PM ;

Stevens, DA ;

Walsh, TJ .

CLINICAL INFECTIOUS DISEASES, 2002, 34 (01) :7-14

[6] Diagnostic Accuracy of PCR Alone Compared to Galactomannan in Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Pulmonary Aspergillosis: a Systematic Review [J].

Avni, Tomer ;

Levy, Itzhak ;

Sprecher, Hannah ;

Yahav, Dafna ;

Leibovici, Leonard ;

Paulf, Mical .

JOURNAL OF CLINICAL MICROBIOLOGY, 2012, 50 (11) :3652-3658

[7] Aspergillosis in Intensive Care Unit (ICU) patients: epidemiology and economic outcomes [J].

Baddley, John W. ;

Stephens, Jennifer M. ;

Ji, Xiang ;

Gao, Xin ;

Schlamm, Haran T. ;

Tarallo, Miriam .

BMC INFECTIOUS DISEASES, 2013, 13

[8] Epidemiology of Invasive Pulmonary Aspergillosis Among Intubated Patients With COVID-19: A Prospective Study [J].

Bartoletti, Michele ;

Pascale, Renato ;

Cricca, Monica ;

Rinaldi, Matteo ;

Maccaro, Angelo ;

Bussini, Linda ;

Fornaro, Giacomo ;

Tonetti, Tommaso ;

Pizzilli, Giacinto ;

Francalanci, Eugenia ;

Giuntoli, Lorenzo ;

Rubin, Arianna ;

Moroni, Alessandra ;

Ambretti, Simone ;

Trapani, Filippo ;

Vatamanu, Oana ;

Ranieri, Vito Marco ;

Castelli, Andrea ;

Baiocchi, Massimo ;

Lewis, Russell ;

Giannella, Maddalena ;

Viale, Pierluigi .

CLINICAL INFECTIOUS DISEASES, 2021, 73 (11) :E3606-E3614

[9] Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, adult patients: A systematic review with qualitative evidence synthesis [J].

Bassetti, M. ;

Giacobbe, D. R. ;

Grecchi, C. ;

Rebuffi, C. ;

Zuccaro, V. ;

Scudeller, L. .

JOURNAL OF INFECTION, 2020, 81 (01) :131-146

[10] A Clinical Algorithm to Diagnose Invasive Pulmonary Aspergillosis in Critically Ill Patients [J].

Blot, Stijn I. ;

Taccone, Fabio Silvio ;

Van den Abeele, Anne-Marie ;

Bulpa, Pierre ;

Meersseman, Wouter ;

Brusselaers, Nele ;

Dimopoulos, George ;

Paiva, Jose A. ;

Misset, Benoit ;

Rello, Jordi ;

Vandewoude, Koenraad ;

Vogelaers, Dirk .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2012, 186 (01) :56-64

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