Mechanisms of Lung Damage and Development of COPD Due to Household Biomass-Smoke Exposure: Inflammation, Oxidative Stress, MicroRNAs, and Gene Polymorphisms

被引:32
|
作者
Ortiz-Quintero, Blanca [1 ]
Martinez-Espinosa, Israel [1 ]
Perez-Padilla, Rogelio [2 ]
机构
[1] Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Dept Res Biochem, Res Unit, Mexico City 14080, DF, Mexico
[2] Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Dept Res Tobacco & Chron Obstruct Pulm Dis COPD, Mexico City 14080, DF, Mexico
关键词
biomass smoke; woodsmoke; household air pollution; lung damage; COPD; pathogenesis mechanisms; OBSTRUCTIVE PULMONARY-DISEASE; GENOME-WIDE ASSOCIATION; RECEPTOR POTENTIAL ANKYRIN-1; HUMAN ALVEOLAR MACROPHAGES; FINE PARTICULATE MATTER; INDOOR AIR-POLLUTION; WILDLAND FIRE SMOKE; WOOD-SMOKE; DNA-DAMAGE; HOSPITAL ADMISSIONS;
D O I
10.3390/cells12010067
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Chronic exposure to indoor biomass smoke from the combustion of solid organic fuels is a major cause of disease burden worldwide. Almost 3 billion people use solid fuels such as wood, charcoal, and crop residues for indoor cooking and heating, accounting for approximately 50% of all households and 90% of rural households globally. Biomass smoke contains many hazardous pollutants, resulting in household air pollution (HAP) exposure that often exceeds international standards. Long-term biomass-smoke exposure is associated with Chronic Obstructive Pulmonary Disease (COPD) in adults, a leading cause of morbidity and mortality worldwide, chronic bronchitis, and other lung conditions. Biomass smoke-associated COPD differs from the best-known cigarette smoke-induced COPD in several aspects, such as a slower decline in lung function, greater airway involvement, and less emphysema, which suggests a different phenotype and pathophysiology. Despite the high burden of biomass-associated COPD, the molecular, genetic, and epigenetic mechanisms underlying its pathogenesis are poorly understood. This review describes the pathogenic mechanisms potentially involved in lung damage, the development of COPD associated with wood-derived smoke exposure, and the influence of genetic and epigenetic factors on the development of this disease.
引用
收藏
页数:34
相关论文
共 5 条
  • [1] Oxidative Stress, Inflammation, and DNA Damage in Rats after Intratracheal Instillation or Oral Exposure to Ambient Air and Wood Smoke Particulate Matter
    Danielsen, Pernille Hogh
    Loft, Steffen
    Jacobsen, Nicklas Raun
    Jensen, Keld Alstrup
    Autrup, Herman
    Ravanat, Jean-Luc
    Wallin, Hakan
    Moller, Peter
    TOXICOLOGICAL SCIENCES, 2010, 118 (02) : 574 - 585
  • [2] Changes in sputum cytology, airway inflammation and oxidative stress due to chronic inhalation of biomass smoke during cooking in premenopausal rural Indian women
    Dutta, Anindita
    Roychoudhury, Sanghita
    Chowdhury, Saswati
    Ray, Manas Ranjan
    INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 2013, 216 (03) : 301 - 308
  • [3] Lung inflammation changes and oxidative stress induced by cigarette smoke exposure in guinea pigs affected by Zataria multiflora and its constituent, carvacrol
    Mohammad Hossein Boskabady
    Leila Gholami Mahtaj
    BMC Complementary and Alternative Medicine, 15
  • [4] Lung inflammation changes and oxidative stress induced by cigarette smoke exposure in guinea pigs affected by Zataria multiflora and its constituent, carvacrol
    Boskabady, Mohammad Hossein
    Mahtaj, Leila Gholami
    BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2015, 15
  • [5] Nose-Only Water-Pipe Smoke Exposure in Mice Elicits Renal Histopathological Alterations, Inflammation, Oxidative Stress, DNA Damage, and Apoptosis
    Nemmar, Abderrahim
    Beegam, Sumaya
    Yuvaraju, Priya
    Yasin, Javed
    Ali, Badreldin H.
    Adeghate, Ernest
    FRONTIERS IN PHYSIOLOGY, 2020, 11