Long COVID: mechanisms, risk factors and recovery

被引：132

作者：

Astin, Ronan ^{[1
,2
]}

Banerjee, Amitava ^{[3
,4
]}

Baker, Mark R. ^{[5
]}

Dani, Melanie ^{[6
]}

Ford, Elizabeth ^{[7
]}

Hull, James H. ^{[8
,9
]}

Lim, Phang Boon ^{[6
]}

McNarry, Melitta ^{[10
]}

Morten, Karl ^{[10
,11
]}

O'Sullivan, Oliver ^{[12
,13
]}

Pretorius, Etheresia ^{[14
,15
]}

Raman, Betty ^{[16
,17
]}

Soteropoulos, Demetris S. ^{[5
]}

Taquet, Maxime ^{[18
,19
]}

Hall, Catherine N. ^{[20
,21
]}

机构：

[1] Univ Coll London Hosp NHS Fdn Trust, Dept Resp Med, London, England

[2] UCL, Ctr Human Hlth & Performance, Inst Sport Exercise & Hlth, London, England

[3] UCL, Inst Hlth Informat, London, England

[4] Barts Hlth NHS Trust, Dept Cardiol, London, England

[5] Newcastle Univ, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England

[6] Imperial Coll Healthcare NHS Trust, Imperial Syncope Unit, London, England

[7] Brighton & Sussex Med Sch, Falmer, England

[8] UCL, Inst Sport Exercise & Hlth ISEH, Div Surg & Intervent Sci, London, England

[9] Royal Brompton Hosp, London, England

[10] Swansea Univ, Appl Sports Technol Exercise & Med Res Ctr, Swansea, W Glam, Wales

[11] Univ Oxford, Nuffield Dept Womens & Reprod Hlth, Oxford, England

[12] Def Med Rehabil Ctr Stanford Hall, Acad Dept Mil Rehabil, Loughborough, Leics, England

[13] Univ Nottingham, Sch Med, Nottingham, England

[14] Stellenbosch Univ, Fac Sci, Dept Physiol Sci, Stellenbosch, South Africa

[15] Univ Liverpool, Fac Hlth & Life Sci, Inst Syst Mol & Integrat Biol, Dept Biochem & Syst Biol, Liverpool, Merseyside, England

[16] Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England

[17] Oxford Univ Hosp NHS Fdn Trust, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England

[18] Univ Oxford, Dept Psychiat, Oxford, England

[19] Oxford Hlth NHS Fdn Trust, Oxford, England

[20] Univ Sussex, Sch Psychol, Falmer BN1 9RH, England

[21] Univ Sussex, Sussex Neurosci, Falmer BN1 9RH, England

来源：

EXPERIMENTAL PHYSIOLOGY | 2023年 / 108卷 / 01期

基金：

美国国家卫生研究院; 英国科研创新办公室;

关键词：

cardiovascular; coagulation; dysautonomia; fatigue; long COVID; ME; CFS; respiratory; SARS-CoV-2; CHRONIC-FATIGUE-SYNDROME; MUSCLE METABOLISM; DOUBLE-BLIND; EXERCISE; SUPPLEMENTATION; SYMPTOMS; NADH; CARE;

D O I：

10.1113/EP090802

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

New FindingsWhat is the topic of this review?The emerging condition of long COVID, its epidemiology, pathophysiological impacts on patients of different backgrounds, physiological mechanisms emerging as explanations of the condition, and treatment strategies being trialled. The review leads from a Physiological Society online conference on this topic.

引用

页码：12 / 27

页数：16

共 144 条

[41] Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions [J].

Flynn, Ryan A. ;

Belk, Julia A. ;

Qi, Yanyan ;

Yasumoto, Yuki ;

Wei, Jin ;

Alfajaro, Mia Madel ;

Shi, Quanming ;

Mumbach, Maxwell R. ;

Limaye, Aditi ;

DeWeirdt, Peter C. ;

Schmitz, Cameron O. ;

Parker, Kevin R. ;

Woo, Elizabeth ;

Chang, Howard Y. ;

Horvath, Tamas L. ;

Carette, Jan E. ;

Bertozzi, Carolyn R. ;

Wilen, Craig B. ;

Satpathy, Ansuman T. .

CELL, 2021, 184 (09) :2394-+

[42] Persistent endotheliopathy in the pathogenesis of long COVID syndrome [J].

Fogarty, Helen ;

Townsend, Liam ;

Morrin, Hannah ;

Ahmad, Azaz ;

Comerford, Claire ;

Karampini, Ellie ;

Englert, Hanna ;

Byrne, Mary ;

Bergin, Colm ;

O'Sullivan, Jamie M. ;

Martin-Loeches, Ignacio ;

Nadarajan, Parthiban ;

Bannan, Ciaran ;

Mallon, Patrick W. ;

Curley, Gerard F. ;

Preston, Roger J. S. ;

Rehill, Aisling M. ;

McGonagle, Dennis ;

Cheallaigh, Cliona Ni ;

Baker, Ross, I ;

Renne, Thomas ;

Ward, Soracha E. ;

O'Donnell, James S. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2021, 19 (10) :2546-2553

[43] Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome [J].

Forsyth, LM ;

Preuss, HG ;

MacDowell, AL ;

Chiazze, L ;

Birkmayer, GD ;

Bellanti, JA .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 1999, 82 (02) :185-191

[44] Coronavirus persistence in human respiratory tract and cell culture: An overview [J].

Gaspar-Rodriguez, Adriana ;

Padilla-Gonzalez, Ana ;

Rivera-Toledo, Evelyn .

BRAZILIAN JOURNAL OF INFECTIOUS DISEASES, 2021, 25 (05)

[45] Update on endothelial dysfunction in COVID-19: severe disease, long COVID-19 and pediatric characteristics [J].

Gavriilaki, Eleni ;

Eftychidis, Ioannis ;

Papassotiriou, Ioannis .

JOURNAL OF LABORATORY MEDICINE, 2021, 45 (06) :293-302

[46] Plasma metabolomics reveals disrupted response and recovery following maximal exercise in myalgic encephalomyelitis/chronic fatigue syndrome [J].

Germain, Arnaud ;

Giloteaux, Ludovic ;

Moore, Geoffrey E. ;

Levine, Susan M. ;

Chia, John K. ;

Keller, Betsy A. ;

Stevens, Jared ;

Franconi, Carl J. ;

Mao, Xiangling ;

Shungu, Dikoma C. ;

Grimson, Andrew ;

Hanson, Maureen R. .

JCI INSIGHT, 2022, 7 (09) :1-21

[47] Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID-19 pneumonia [J].

Gibellini, Lara ;

De Biasi, Sara ;

Paolini, Annamaria ;

Borella, Rebecca ;

Boraldi, Federica ;

Mattioli, Marco ;

Lo Tartaro, Domenico ;

Fidanza, Lucia ;

Caro-Maldonado, Alfredo ;

Meschiari, Marianna ;

Iadisernia, Vittorio ;

Bacca, Erica ;

Riva, Giovanni ;

Cicchetti, Luca ;

Quaglino, Daniela ;

Guaraldi, Giovanni ;

Busani, Stefano ;

Girardis, Massimo ;

Mussini, Cristina ;

Cossarizza, Andrea .

EMBO MOLECULAR MEDICINE, 2020, 12 (12)

[48] Adapting the UK Biobank Brain Imaging Protocol and Analysis Pipeline for the C-MORE Multi-Organ Study of COVID-19 Survivors [J].

Griffanti, Ludovica ;

Raman, Betty ;

Alfaro-Almagro, Fidel ;

Filippini, Nicola ;

Cassar, Mark Philip ;

Sheerin, Fintan ;

Okell, Thomas W. ;

Kennedy McConnell, Flora A. ;

Chappell, Michael A. ;

Wang, Chaoyue ;

Arthofer, Christoph ;

Lange, Frederik J. ;

Andersson, Jesper ;

Mackay, Clare E. ;

Tunnicliffe, Elizabeth M. ;

Rowland, Matthew ;

Neubauer, Stefan ;

Miller, Karla L. ;

Jezzard, Peter ;

Smith, Stephen M. .

FRONTIERS IN NEUROLOGY, 2021, 12

[49] SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19 [J].

Grobbelaar, Lize M. ;

Venter, Chantelle ;

Vlok, Mare ;

Ngoepe, Malebogo ;

Laubscher, Gert Jacobus ;

Lourens, Petrus Johannes ;

Steenkamp, Janami ;

Kell, Douglas B. ;

Pretorius, Etheresia .

BIOSCIENCE REPORTS, 2021, 41 (08)

[50] Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes [J].

Grobler, Corlia ;

Maphumulo, Siphosethu C. ;

Grobbelaar, L. Mireille ;

Bredenkamp, Jhade C. ;

Laubscher, Gert J. ;

Lourens, Petrus J. ;

Steenkamp, Janami ;

Kell, Douglas B. ;

Pretorius, Etheresia .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (14) :1-25

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