Controlled delivery of aspirin from nanocellulose-sodium alginate interpenetrating network hydrogels

被引：32

作者：

Ma, Huazhong ^{[1
]}

Zhao, Jianglin ^{[1
]}

Liu, Ying ^{[1
]}

Liu, Liang ^{[1
]}

Yu, Juan ^{[1
]}

Fan, Yimin ^{[1
]}

机构：

[1] Nanjing Forestry Univ, Coll Chem Engn, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat Fo, Int Innovat Ctr Forest Chem & Mat, Nanjing 210037, Peoples R China

来源：

INDUSTRIAL CROPS AND PRODUCTS | 2023年 / 192卷

关键词：

Nanocellulose; IPN hydrogel; Drug delivery; Sodium alginate; POLYMER NETWORK; SUSTAINED-RELEASE; NANOPARTICLES; DESIGN;

D O I：

10.1016/j.indcrop.2022.116081

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

An interpenetrating network (IPN) hydrogel was developed by the miscibility between nanocellulose and sodium alginate through an acetic acid coagulation bath and Ca2+ chelation. Double crosslinking played a key role during the construction of the IPN hydrogel network. The nanofibers significantly prolonged the aspirin release time to similar to 60 h, which benefits from the rich and regular network structure of the hydrogel. Carboxyl groups contribute to the variation in release capacity in different pH environments. The strategy proposed in this study would guide the preparation of purely physically crosslinked IPN hydrogels with good mechanical properties and cytocompatibility and their application in the drug delivery field. This study aimed to explore the double crosslinking process for prolonged aspirin release capacity between nanocellulose and sodium alginate. The obtained results suggested that a pH-sensitive nanocellulose-sodium alginate IPN hydrogel would be an ideal aspirin carrier for long-term release.

引用

页数：12