A review of rabbit models of meibomian gland dysfunction and scope for translational research

被引:9
作者
Prasad, Deeksha [1 ,2 ]
Salman, Mohd [1 ,2 ]
Reddy, A. Anirudh [1 ]
Jaffet, Jilu [1 ,2 ]
Sahoo, Abhishek [1 ]
Jakati, Saumya [3 ]
Bokara, Kiran Kumar [4 ]
Singh, Swati [5 ]
Basu, Sayan [1 ]
Singh, Vivek [1 ,8 ]
Donthineni, Pragnya Rao [6 ,7 ]
机构
[1] LV Prasad Eye Inst, Brien Holden Eye Res Ctr, Ctr Ocular Regenerat, Hyderabad, Telangana, Pakistan
[2] Manipal Acad Higher Educ, Manipal, Karnataka, India
[3] LV Prasad Eye Inst, Ophthalm Pathol Lab, Hyderabad, Telangana, Pakistan
[4] CSIR Ctr Cellular & Mol Biol, ANNEXE 2,Med Biotechnol Complex,Uppal Rd, Hyderabad, Telangana, Pakistan
[5] V Prasad Eye Inst, Ophthalm Plast Surg Serv, Hyderabad, Telangana, Pakistan
[6] LV Prasad Eye Inst, Shantilal Shanghvi Cornea Inst, Hyderabad, Telangana, India
[7] LV Prasad Eye Inst, Shantilal Shanghvi Cornea Inst, Rd 2,Banjara Hills, Hyderabad 500034, Telangana, India
[8] LV Prasad Eye Inst, Prof Brien Holden Eye Res Ctr, Rd 2,Banjara Hills, Hyderabad 500034, Telangana, India
关键词
Animal models; dry eye; dry eye animal model; evaporative dry eye; meibomian gland dysfunction; rabbit dry eye model; DRY EYE DISEASE; OCULAR SURFACE CHANGES; TEAR FILM; INTERNATIONAL WORKSHOP; 13-CIS-RETINOIC ACID; ANIMAL-MODELS; SUBCOMMITTEE; PREVALENCE; LIPIDS; MOUSE;
D O I
10.4103/IJO.IJO_2815_22
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Dry eye disease (DED) is an emerging global health concern with meibomian gland dysfunction (MGD) being the most common subtype of DED. Despite being quite prevalent, the pathophysiological mechanisms governing MGD are poorly understood. Animal models for MGD can be a valuable resource to advance our understanding of this entity and explore novel diagnostic and therapeutic modalities. Although a lot of literature on rodent MGD models exists, a comprehensive review on rabbit animal models is lacking. Rabbits offer a great advantage over other animals as models for studying both DED and MGD. Rabbits have a widely exposed ocular surface and meibomian gland anatomy comparable with humans, which makes performing dry eye diagnostic tests possible using clinically validated imaging platforms. The existing MGD models in rabbits can broadly be classified as pharmacologically induced and surgically induced models. Most models show keratinization of the meibomian gland orifice with plugging as the final common pathway for developing MGD. Thus, understanding the advantages and disadvantages of each rabbit MGD model can help researchers choose the appropriate experimental plan based on the objective of the study. In this review, we discuss the comparative anatomy of the meibomian glands in humans and rabbits, various rabbit models of MGD, translational applications, unmet needs, and future directions in developing MGD models in rabbits.
引用
收藏
页码:1227 / 1236
页数:10
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