MG53: A potential therapeutic target for kidney disease

被引：2

作者：

Ke, Ben ^{[1
,3
]}

Shen, Wen ^{[2
]}

Song, Jianling ^{[1
]}

Fang, Xiangdong ^{[1
,3
]}

机构：

[1] Nanchang Univ, Affiliated Hosp 2, Dept Nephrol, Nanchang, Jiangxi, Peoples R China

[2] Nanchang Univ, Affiliated Hosp 2, Dept Cardiovasc Med, Nanchang, Peoples R China

[3] Minde Rd, Nanchang 330006, Peoples R China

来源：

PHARMACOLOGY RESEARCH & PERSPECTIVES | 2023年 / 11卷 / 01期

基金：

中国国家自然科学基金;

关键词：

acute kidney injury; clinical application; kidney fibrosis; membrane repair; MG53; INSULIN-RESISTANCE; MEMBRANE REPAIR; METABOLIC SYNDROME; INJURY; CKD; TRANSCRIPTION; DYSFUNCTION; MIGRATION; PROTEINS; FIBROSIS;

D O I：

10.1002/prp2.1049

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ensuring cell survival and tissue regeneration by maintaining cellular integrity is important to the pathophysiology of many human diseases, including kidney disease. Mitsugumin 53 (MG53) is a member of the tripartite motif-containing (TRIM) protein family that plays an essential role in repairing cell membrane injury and improving tissue regeneration. In recent years, an increasing number of studies have demonstrated that MG53 plays a renoprotective role in kidney diseases. Moreover, with the beneficial effects of the recombinant human MG53 (rhMG53) protein in the treatment of kidney diseases in different animal models, rhMG53 shows significant therapeutic potential in kidney disease. In this review, we elucidate the role of MG53 and its molecular mechanism in kidney disease to provide new approaches to the treatment of kidney disease.

引用

页数：6

共 67 条

[1] TRIM Proteins in Therapeutic Membrane Repair of Muscular Dystrophy [J].

Alloush, Jenna ;

Weisleder, Noah .

JAMA NEUROLOGY, 2013, 70 (07) :928-931

[2] The impact of insulin resistance on the kidney and vasculature [J].

Artunc, Ferruh ;

Schleicher, Erwin ;

Weigert, Cora ;

Fritsche, Andreas ;

Stefan, Norbert ;

Haering, Hans-Ulrich .

NATURE REVIEWS NEPHROLOGY, 2016, 12 (12) :721-737

[3] Regardless of etiology, progressive renal disease causes ultrastructural and functional alterations of peritubular capillaries [J].

Babickova, Janka ;

Klinkhammer, Barbara M. ;

Buhl, Eva M. ;

Djudjaj, Sonja ;

Hoss, Mareike ;

Heymann, Felix ;

Tacke, Frank ;

Floege, Juergen ;

Becker, Jan U. ;

Boor, Peter .

KIDNEY INTERNATIONAL, 2017, 91 (01) :70-85

[4] Chronic kidney disease causes defects in signaling through the insulin receptor sub strate/phosphatidylinositol 3-kinase/Akt pathway: Implications for muscle atrophy [J].

Bailey, James L. ;

Zheng, Bin ;

Hu, Zhaoyong ;

Price, S. Russ ;

Mitch, William E. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 (05) :1388-1394

[5] The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent ubiquitin-proteasome pathway [J].

Bailey, JL ;

Wang, XN ;

England, BK ;

Price, SR ;

Ding, XY ;

Mitch, WE .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (06) :1447-1453

[6] Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 [J].

Bikbov, Boris ;

Purcell, Carrie ;

Levey, Andrew S. ;

Smith, Mari ;

Abdoli, Amir ;

Abebe, Molla ;

Adebayo, Oladimeji M. ;

Afarideh, Mohsen ;

Agarwal, Sanjay Kumar ;

Agudelo-Botero, Marcela ;

Ahmadian, Elham ;

Al-Aly, Ziyad ;

Alipour, Vahid ;

Almasi-Hashiani, Amir ;

Al-Raddadi, Rajaa M. ;

Alvis-Guzman, Nelson ;

Amini, Saeed ;

Andrei, Tudorel ;

Andrei, Catalina Liliana ;

Andualem, Zewudu ;

Anjomshoa, Mina ;

Arabloo, Jalal ;

Ashagre, Alebachew Fasil ;

Asmelash, Daniel ;

Ataro, Zerihun ;

Atout, Maha Moh'd Wahbi ;

Ayanore, Martin Amogre ;

Badawi, Alaa ;

Bakhtiari, Ahad ;

Ballew, Shoshana H. ;

Balouchi, Abbas ;

Banach, Maciej ;

Barquera, Simon ;

Basu, Sanjay ;

Bayih, Mulat Tirfie ;

Bedi, Neeraj ;

Bello, Aminu K. ;

Bensenor, Isabela M. ;

Bijani, Ali ;

Boloor, Archith ;

Borzi, Antonio M. ;

Camera, Luis Alberto ;

Carrero, Juan J. ;

Carvalho, Felix ;

Castro, Franz ;

Catala-Lopez, Ferran ;

Chang, Alex R. ;

Chin, Ken Lee ;

Chung, Sheng-Chia ;

Cirillo, Massimo .

LANCET, 2020, 395 (10225) :709-733

[7] MG53 nucleates assembly of cell membrane repair machinery [J].

Cai, Chuanxi ;

Masumiya, Haruko ;

Weisleder, Noah ;

Matsuda, Noriyuki ;

Nishi, Miyuki ;

Hwang, Moonsun ;

Ko, Jae-Kyun ;

Lin, Peihui ;

Thornton, Angela ;

Zhao, Xiaoli ;

Pan, Zui ;

Komazaki, Shinji ;

Brotto, Marco ;

Takeshima, Hiroshi ;

Ma, Jianjie .

NATURE CELL BIOLOGY, 2009, 11 (01) :56-U108

[8] Contrast-induced acute kidney injury and diabetic nephropathy [J].

Calvin, Andrew D. ;

Misra, Sanjay ;

Pflueger, Axel .

NATURE REVIEWS NEPHROLOGY, 2010, 6 (11) :679-688

[9] Cyclin G1 and TASCC regulate kidney epithelial cell G2-M arrest and fibrotic maladaptive repair [J].

Canaudl, Guillaume ;

Brooks, Craig R. ;

Kishi, Seiji ;

Taguchi, Kensei ;

Nishimura, Kenji ;

Magassa, Sato ;

Scott, Adam ;

Hsiao, Li-Li ;

Ichimura, Takaharu ;

Terzi, Fabiola ;

Yang, Li ;

Bonventre, Joseph, V .

SCIENCE TRANSLATIONAL MEDICINE, 2019, 11 (476)

[10] MG53 Constitutes a Primary Determinant of Cardiac Ischemic Preconditioning [J].

Cao, Chun-Mei ;

Zhang, Yan ;

Weisleder, Noah ;

Ferrante, Christopher ;

Wang, Xianhua ;

Lv, Fengxiang ;

Zhang, Yi ;

Song, Ruisheng ;

Hwang, Moonsun ;

Jin, Li ;

Guo, Jiaojiao ;

Peng, Wei ;

Li, Geng ;

Nishi, Miyuki ;

Takeshima, Hiroshi ;

Ma, Jianjie ;

Xiao, Rui-Ping .

CIRCULATION, 2010, 121 (23) :2565-U74

← 1 2 3 4 5 6 7 →