Microbiome epidemiology and association studies in human health

被引：38

作者：

VanEvery, Hannah ^{[1
,2
,3
,4
,5
]}

Franzosa, Eric A. ^{[1
,4
,6
]}

Nguyen, Long H. ^{[1
,2
,3
,4
,5
]}

Huttenhower, Curtis ^{[1
,4
,6
,7
]}

机构：

[1] Harvard TH Chan Sch Publ Hlth, Harvard Chan Microbiome Publ Hlth Ctr, Boston, MA 02115 USA

[2] Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA

[3] Harvard Med Sch, Boston, MA 02115 USA

[4] Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[5] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA

[6] Broad Inst MIT & Harvard, Infect Dis & Microbiome Program, Cambridge, MA 02142 USA

[7] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

来源：

NATURE REVIEWS GENETICS | 2023年 / 24卷 / 02期

关键词：

HUMAN GUT MICROBIOME; INTESTINAL MICROBIOTA; METHANOBREVIBACTER-SMITHII; FUSOBACTERIUM-NUCLEATUM; BACTERIAL COMMUNITIES; ESCHERICHIA-COLI; WIDE ASSOCIATION; HOST GENETICS; METABOLISM; DIVERSITY;

D O I：

10.1038/s41576-022-00529-x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Studies of the human microbiome share both technical and conceptual similarities with genome-wide association studies and genetic epidemiology. However, the microbiome has many features that differ from genomes, such as its temporal and spatial variability, highly distinct genetic architecture and person-to-person variation. Moreover, there are various potential mechanisms by which distinct aspects of the human microbiome can relate to health outcomes. Recent advances, including next-generation sequencing and the proliferation of multi-omic data types, have enabled the exploration of the mechanisms that connect microbial communities to human health. Here, we review the ways in which features of the microbiome at various body sites can influence health outcomes, and we describe emerging opportunities and future directions for advanced microbiome epidemiology.

引用

页码：109 / 124

页数：16

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