The role of TIM-3 in sepsis: a promising target for immunotherapy?

被引：5

作者：

Wang, Changli ^{[1
]}

Liu, Jinhai ^{[1
]}

Wu, Qi ^{[1
]}

Wang, Zhi ^{[1
]}

Hu, Baoji ^{[2
]}

Bo, Lulong ^{[1
]}

机构：

[1] Naval Med Univ, Changhai Hosp, Fac Anesthesiol, Shanghai, Peoples R China

[2] Fudan Univ, Shanghai Pudong Hosp, Dept Anesthesiol, Pudong Med Ctr, Shanghai, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

基金：

中国国家自然科学基金;

关键词：

TIM-3; Sepsis; immunotherapy; inflammatory response; therapeutic target; T-CELL IMMUNOGLOBULIN; SIGNALING PATHWAY; RECEPTOR TIM-3; RESPONSES; INFLAMMATION; ACTIVATION; SEVERITY; BLOCKADE; LAG-3; IG;

D O I：

10.3389/fimmu.2024.1328667

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sepsis remains a significant cause of mortality and morbidity worldwide, with limited effective treatment options. The T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) has emerged as a potential therapeutic target in various immune-related disorders. This narrative review aims to explore the role of TIM-3 in sepsis and evaluate its potential as a promising target for immunotherapy. We discuss the dynamic expression patterns of TIM-3 during sepsis and its involvement in regulating immune responses. Furthermore, we examine the preclinical studies investigating the regulation of TIM-3 signaling pathways in septic models, highlighting the potential therapeutic benefits and challenges associated with targeting TIM-3. Overall, this review emphasizes the importance of TIM-3 in sepsis pathogenesis and underscores the promising prospects of TIM-3-based immunotherapy as a potential strategy to combat this life-threatening condition.

引用

页数：10

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