The causal relationship between physical activity, sedentary behavior and brain cortical structure: a Mendelian randomization study

被引:3
作者
Sun, Yulin [1 ]
Ma, Di [1 ]
Jiang, Zhenping [1 ]
Han, Qifeng [2 ]
Liu, Yining [1 ]
Chen, Guoyang [1 ]
机构
[1] Hanyang Univ ERICA, Dept Sports Sci, 55 Hanyangdaehak Ro, Ansan 15588, South Korea
[2] Hanyang Univ, Dept Phys Educ, 222 Wangsimni Ro, Seoul 04763, South Korea
关键词
brain cortical structure; causal effect; Mendelian randomization; physical activity; sedentary behavior; INSTRUMENTS; RISK; BIAS;
D O I
10.1093/cercor/bhae119
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Physical activity and sedentary behavior, both distinct lifestyle behaviors associated with brain health, have an unclear potential relationship with brain cortical structure. This study aimed to determine the causal link between physical activity, sedentary behavior, and brain cortical structure (cortical surface area and thickness) through Mendelian randomization analysis. The inverse-variance weighted method was primarily utilized, accompanied by sensitivity analyses, to confirm the results' robustness and accuracy. Analysis revealed nominally significant findings, indicating a potential positive influence of physical activity on cortical thickness in the bankssts (beta = 0.002 mm, P = 0.043) and the fusiform (beta = 0.002 mm, P = 0.018), and a potential negative association of sedentary behavior with cortical surface area in the caudal middle frontal (beta = -34.181 mm2, P = 0.038) and the pars opercularis (beta = -33.069 mm2, P = 0.002), alongside a nominally positive correlation with the cortical surface area of the inferior parietal (beta = 58.332 mm2, P = 0.035). Additionally, a nominally significant negative correlation was observed between sedentary behavior and cortical thickness in the paracentral (beta = -0.014 mm, P = 0.042). These findings offer insights into how lifestyle behaviors may influence brain cortical structures, advancing our understanding of their interaction with brain health.
引用
收藏
页数:7
相关论文
共 37 条
[11]   An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest [J].
Desikan, Rahul S. ;
Segonne, Florent ;
Fischl, Bruce ;
Quinn, Brian T. ;
Dickerson, Bradford C. ;
Blacker, Deborah ;
Buckner, Randy L. ;
Dale, Anders M. ;
Maguire, R. Paul ;
Hyman, Bradley T. ;
Albert, Marilyn S. ;
Killiany, Ronald J. .
NEUROIMAGE, 2006, 31 (03) :968-980
[12]   GWAS identifies 14 loci for device-measured physical activity and sleep duration [J].
Doherty, Aiden ;
Smith-Byrne, Karl ;
Ferreira, Teresa ;
Holmes, Michael V. ;
Holmes, Chris ;
Pulit, Sara L. ;
Lindgren, Cecilia M. .
NATURE COMMUNICATIONS, 2018, 9
[13]   Is Objectively Assessed Sedentary Behavior, Physical Activity and Cardiorespiratory Fitness Linked to Brain Plasticity Outcomes in Old Age? [J].
Engeroff, Tobias ;
Fuezeki, Eszter ;
Vogt, Lutz ;
Fleckenstein, Johannes ;
Schwarz, Sina ;
Matura, Silke ;
Pilatus, Ulrich ;
Deichmann, Ralf ;
Hellweg, Rainer ;
Pantel, Johannes ;
Banzer, Winfried .
NEUROSCIENCE, 2018, 388 :384-392
[14]   Exercise training increases size of hippocampus and improves memory [J].
Erickson, Kirk I. ;
Voss, Michelle W. ;
Prakash, Ruchika Shaurya ;
Basak, Chandramallika ;
Szabo, Amanda ;
Chaddock, Laura ;
Kim, Jennifer S. ;
Heo, Susie ;
Alves, Heloisa ;
White, Siobhan M. ;
Wojcicki, Thomas R. ;
Mailey, Emily ;
Vieira, Victoria J. ;
Martin, Stephen A. ;
Pence, Brandt D. ;
Woods, Jeffrey A. ;
McAuley, Edward ;
Kramer, Arthur F. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (07) :3017-3022
[15]   What is the association between sedentary behaviour and cognitive function? A systematic review [J].
Falck, Ryan S. ;
Davis, Jennifer C. ;
Liu-Ambrose, Teresa .
BRITISH JOURNAL OF SPORTS MEDICINE, 2017, 51 (10) :800-811
[16]   Effect of Naturally Random Allocation to Lower Low-Density Lipoprotein Cholesterol on the Risk of Coronary Heart Disease Mediated by Polymorphisms in NPC1L1, HMGCR, or Both [J].
Ference, Brian A. ;
Majeed, Faisal ;
Penumetcha, Raju ;
Flack, John M. ;
Brook, Robert D. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2015, 65 (15) :1552-1561
[17]   The genetic architecture of the human cerebral cortex [J].
Grasby, Katrina L. ;
Jahanshad, Neda ;
Painter, Jodie N. ;
Colodro-Conde, Lucia ;
Bralten, Janita ;
Hibar, Derrek P. ;
Lind, Penelope A. ;
Pizzagalli, Fabrizio ;
Ching, Christopher R. K. ;
McMahon, Mary Agnes B. ;
Shatokhina, Natalia ;
Zsembik, Leo C. P. ;
Thomopoulos, Sophia I. ;
Zhu, Alyssa H. ;
Strike, Lachlan T. ;
Agartz, Ingrid ;
Alhusaini, Saud ;
Almeida, Marcio A. A. ;
Alnaes, Dag ;
Amlien, Inge K. ;
Andersson, Micael ;
Ard, Tyler ;
Armstrong, Nicola J. ;
Ashley-Koch, Allison ;
Atkins, Joshua R. ;
Bernard, Manon ;
Brouwer, Rachel M. ;
Buimer, Elizabeth E. L. ;
Bulow, Robin ;
Burger, Christian ;
Cannon, Dara M. ;
Chakravarty, Mallar ;
Chen, Qiang ;
Cheung, Joshua W. ;
Couvy-Duchesne, Baptiste ;
Dale, Anders M. ;
Dalvie, Shareefa ;
de Araujo, Tania K. ;
de Zubicaray, Greig I. ;
de Zwarte, Sonja M. C. ;
den Braber, Anouk ;
Nhat Trung Doan ;
Dohm, Katharina ;
Ehrlich, Stefan ;
Engelbrecht, Hannah-Ruth ;
Erk, Susanne ;
Fan, Chun Chieh ;
Fedko, Iryna O. ;
Foley, Sonya F. ;
Ford, Judith M. .
SCIENCE, 2020, 367 (6484) :1340-+
[18]   A Practical Review of Functional MRI Anatomy of the Language and Motor Systems [J].
Hill, V. B. ;
Cankurtaran, C. Z. ;
Liu, B. P. ;
Hijaz, T. A. ;
Naidich, M. ;
Nemeth, A. J. ;
Gastala, J. ;
Krumpelman, C. ;
McComb, E. N. ;
Korutz, A. W. .
AMERICAN JOURNAL OF NEURORADIOLOGY, 2019, 40 (07) :1084-1090
[19]   Regional grey matter shrinks in hypertensive individuals despite successful lowering of blood pressure [J].
Jennings, J. R. ;
Mendelson, D. N. ;
Muldoon, M. F. ;
Ryan, C. M. ;
Gianaros, P. J. ;
Raz, N. ;
Aizenstein, H. .
JOURNAL OF HUMAN HYPERTENSION, 2012, 26 (05) :295-305
[20]   PhenoScanner V2: an expanded tool for searching human genotype-phenotype associations [J].
Kamat, Mihir A. ;
Blackshaw, James A. ;
Young, Robin ;
Surendran, Praveen ;
Burgess, Stephen ;
Danesh, John ;
Butterworth, Adam S. ;
Staley, James R. .
BIOINFORMATICS, 2019, 35 (22) :4851-4853