The impact of interaction between verteporfin and yes-associated protein 1/transcriptional coactivator with PDZ-binding motif-TEA domain pathway on the progression of isocitrate dehydrogenase wild-type glioblastoma

被引：5

作者：

Osama, Mahmoud ^{[1
,2
]}

Essibayi, Muhammed Amir ^{[3
,4
]}

Osama, Mona ^{[5
]}

Ibrahim, Ismail A. ^{[6
]}

Mostafa, Mostafa Nasr ^{[2
]}

Eksi, Murat Sakir ^{[7
]}

机构：

[1] Nasser Inst Res & Treatment, Dept Neurosurg, Maahad Nasser St As Sahel, Cairo 4350210, Egypt

[2] Zagazig Univ, Fac Med, Zagazig, Egypt

[3] Albert Einstein Coll Med, Dept Neurosurg, New York, NY USA

[4] Mayo Clin, Dept Radiol, Rochester, MN USA

[5] Zagazig Univ, Fac Pharm, Zagazig, Egypt

[6] Fenerbahce Univ, Dept Phys Therapy & Rehabil, Istanbul, Turkiye

[7] FSM Training & Res Hosp, Neurosurg Clin, Istanbul, Turkiye

来源：

JOURNAL OF CENTRAL NERVOUS SYSTEM DISEASE | 2023年 / 15卷

关键词：

Glioblastoma; verteporfin; YAP; TAZ-TEAD pathway; glioblastoma stem cells; ferroptosis; HIPPO SIGNALING PATHWAY; ORGAN SIZE CONTROL; PHOTODYNAMIC THERAPY; TRANSCRIPTION FACTORS; CELL-PROLIFERATION; BRAIN-TUMORS; YAP-TEAD; TAZ; EXPRESSION; MULTIFORME;

D O I：

10.1177/11795735231195760

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Verteporfin and 5-ALA are used for visualizing malignant tissue components in different body tumors and as photodynamic therapy in treating isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM). Additionally, verteporfin interferes with Yes-associated protein 1 (YAP)/Transcriptional coactivator with PDZ-binding motif - TEA domain (TAZ-TEAD) pathway, thus inhibiting the downstream effect of these oncogenes and reducing the malignant properties of GBM. Animal studies have shown verteporfin to be successful in increasing survival rates, which have led to the conduction of phase 1 and 2 clinical trials to further investigate its efficacy in treating GBM. In this article, we aimed to review the novel mechanism of verteporfin's action, the impact of its interaction with YAP/TAZ-TEAD, its effect on glioblastoma stem cells, and its role in inducing ferroptosis.

引用

页数：8

共 85 条

[1] Verteporfin inhibits growth of human glioma in vitro without light activation [J].

Al-Moujahed, Ahmad ;

Brodowska, Katarzyna ;

Stryjewski, Tomasz P. ;

Efstathiou, Nikolaos E. ;

Vasilikos, Ioannis ;

Cichy, Joanna ;

Miller, Joan W. ;

Gragoudas, Evangelos ;

Vavvas, Demetrios G. .

SCIENTIFIC REPORTS, 2017, 7

[2] Wild-type isocitrate dehydrogenase under the spotlight in glioblastoma [J].

Alzial, Gabriel ;

Renoult, Ophelie ;

Paris, Francois ;

Gratas, Catherine ;

Clavreul, Anne ;

Pecqueur, Claire .

ONCOGENE, 2022, 41 (05) :613-621

[3] A bibliometric review of drug repurposing [J].

Baker, Nancy C. ;

Ekins, Sean ;

Williams, Antony J. ;

Tropsha, Alexander .

DRUG DISCOVERY TODAY, 2018, 23 (03) :661-672

[4] Anti-invasive efficacy and survival benefit of the YAP-TEAD inhibitor Verteporfin in preclinical glioblastoma models [J].

Barrette, Anne Marie ;

Ronk, Halle ;

Joshi, Tanvi ;

Mussa, Zarmeen ;

Mehrotra, Meenakshi ;

Bouras, Alexandros ;

Nudelman, German ;

Raj, Joe G. Jesu ;

Bozec, Dominique ;

Lam, William ;

Houldsworth, Jane ;

Yong, Raymund ;

Zaslavsky, Elena ;

Hadjipanayis, Constantinos G. ;

Birtwistle, Marc R. ;

Tsankova, Nadejda M. .

NEURO-ONCOLOGY, 2022, 24 (05) :694-707

[5]

Baskaran Rengarajan, 2018, Biomater Res, V22, P25

[6] Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis [J].

Basu, S ;

Totty, NF ;

Irwin, MS ;

Sudol, M ;

Downward, J .

MOLECULAR CELL, 2003, 11 (01) :11-23

[7] Glioblastoma Multiforme, Diagnosis and Treatment; Recent Literature Review [J].

Batash, Ron ;

Asna, Noam ;

Schaffer, Pamela ;

Francis, Nicole ;

Schaffer, Moshe .

CURRENT MEDICINAL CHEMISTRY, 2017, 24 (27) :3002-3009

[8] PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3 [J].

Benitez, Jorge A. ;

Ma, Jianhui ;

D'Antonio, Matteo ;

Boyer, Antonia ;

Camargo, Maria Fernanda ;

Zanca, Ciro ;

Kelly, Stephen ;

Khodadadi-Jamayran, Alireza ;

Jameson, Nathan M. ;

Andersen, Michael ;

Miletic, Hrvoje ;

Saberi, Shahram ;

Frazer, Kelly A. ;

Cavenee, Webster K. ;

Furnari, Frank B. .

NATURE COMMUNICATIONS, 2017, 8

[9]

Bhavsar A, 2004, RETINA-J RET VIT DIS, V24, P512

[10] The Somatic Genomic Landscape of Glioblastoma [J].

Brennan, Cameron W. ;

Verhaak, Roel G. W. ;

McKenna, Aaron ;

Campos, Benito ;

Noushmehr, Houtan ;

Salama, Sofie R. ;

Zheng, Siyuan ;

Chakravarty, Debyani ;

Sanborn, J. Zachary ;

Berman, Samuel H. ;

Beroukhim, Rameen ;

Bernard, Brady ;

Wu, Chang-Jiun ;

Genovese, Giannicola ;

Shmulevich, Ilya ;

Barnholtz-Sloan, Jill ;

Zou, Lihua ;

Vegesna, Rahulsimham ;

Shukla, Sachet A. ;

Ciriello, Giovanni ;

Yung, W. K. ;

Zhang, Wei ;

Sougnez, Carrie ;

Mikkelsen, Tom ;

Aldape, Kenneth ;

Bigner, Darell D. ;

Van Meir, Erwin G. ;

Prados, Michael ;

Sloan, Andrew ;

Black, Keith L. ;

Eschbacher, Jennifer ;

Finocchiaro, Gaetano ;

Friedman, William ;

Andrews, David W. ;

Guha, Abhijit ;

Iacocca, Mary ;

O'Neill, Brian P. ;

Foltz, Greg ;

Myers, Jerome ;

Weisenberger, Daniel J. ;

Penny, Robert ;

Kucherlapati, Raju ;

Perou, Charles M. ;

Hayes, D. Neil ;

Gibbs, Richard ;

Marra, Marco ;

Mills, Gordon B. ;

Lander, Eric ;

Spellman, Paul ;

Wilson, Richard .

CELL, 2013, 155 (02) :462-477

← 1 2 3 4 5 6 7 8 9 →