Increase in invasive group A streptococcal infections and emergence of novel, rapidly expanding sub-lineage of the virulent Streptococcus pyogenes M1 clone, Denmark, 2023

被引：64

作者：

Johannesen, Thor Bech ^{[1
]}

Munkstrup, Charlotte ^{[2
]}

Edslev, Sofie Marie ^{[1
]}

Baig, Sharmin ^{[1
]}

Nielsen, Stine ^{[2
]}

Funk, Tjede ^{[2
]}

Kristensen, Dennis Karsten ^{[3
]}

Jacobsen, Lars Hervig ^{[3
]}

Ravn, Signe Fischer ^{[3
]}

Bindslev, Niels ^{[3
]}

Gubbels, Sophie ^{[3
]}

Voldstedlund, Marianne ^{[3
]}

Jokelainen, Pikka ^{[4
]}

Hallstrom, Soren ^{[1
]}

Rasmussen, Astrid ^{[1
]}

Kristinsson, Karl Gustaf ^{[5
,6
]}

Fuglsang-Damgaard, David ^{[7
]}

Dessau, Ram B. ^{[8
,9
]}

Olsen, Agnieszka Barbara ^{[10
]}

Jensen, Christian Salgaard ^{[11
]}

Skovby, Annette ^{[12
]}

Ellermann-Eriksen, Svend ^{[13
]}

Jensen, Thoger Gorm ^{[14
,15
]}

Dzajic, Esad ^{[16
]}

Ostergaard, Claus ^{[17
]}

Andersen, Steen Lomborg ^{[18
]}

Hoffmann, Steen ^{[1
]}

HenrikAndersen, Peter ^{[2
]}

Stegger, Marc ^{[1
,19
]}

机构：

[1] Statens Serum Inst, Bacteria Parasites & Fungi, Copenhagen, Denmark

[2] Statens Serum Inst, Infect Dis Epidemiol & Prevent, Copenhagen, Denmark

[3] Statens Serum Inst, Data Integrat & Anal, Copenhagen, Denmark

[4] Statens Serum Inst, Infect Dis Preparedness, Copenhagen, Denmark

[5] Landspitali Natl Univ Hosp, Dept Clin Microbiol, Reykjavik, Iceland

[6] Univ Iceland, Fac Med, Reykjavik, Iceland

[7] Aalborg Univ Hosp, Dept Clin Microbiol, Aalborg, Denmark

[8] Zealand Univ Hosp, Dept Clin Microbiol, Slagelse, Denmark

[9] Univ Southern Denmark, Dept Reg Hlth Res, Odense, Denmark

[10] Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Microbiol, Herlev, Denmark

[11] Rigshosp, Dept Clin Microbiol, Copenhagen, Denmark

[12] Copenhagen Univ Hosp Amager & Hvidovre, Hvidovre, Denmark

[13] Aarhus Univ Hosp, Dept Clin Microbiol, Aarhus, Denmark

[14] Odense Univ Hosp, Dept Clin Microbiol, Odense, Denmark

[15] Res Unit Clin Microbiol, Odense, Denmark

[16] Univ Hosp Southern Denmark, Hosp South West Jutland, Clin Diagnost Dept, Clin Microbiol, Esbjerg, Denmark

[17] Univ Hosp Southern Denmark, Lillebaelt Hosp, Dept Clin Microbiol, Vejle, Denmark

[18] Univ Hosp Southern Denmark, Sonderjylland Hosp, Dept Clin Microbiol, Aabenraa, Denmark

[19] Murdoch Univ, Harry Butler Inst, Antimicrobial Resistance & Infect Dis Lab, Perth, Australia

来源：

EUROSURVEILLANCE | 2023年 / 28卷 / 26期

关键词：

Denmark; Iceland; M1; M1DK; Streptococcus pyogenes; bacterial genomics; group A Streptococcus; virulence;

D O I：

10.2807/1560-7917.ES.2023.28.26.2300291

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A highly virulent sub-lineage of the Streptococcus pyogenes M1 clone has been rapidly expanding throughout Denmark since late 2022 and now accounts for 30% of the new invasive group A streptococcal infections. We aimed to investigate whether a shift in variant composition can account for the high incidence rates observed over winter 2022/23, or if these are better explained by the impact of COVID-19-related restrictions on population immunity and carriage of group A Streptococcus.

引用

页数：6

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