Baseline PET radiomics outperforms the IPI risk score for prediction of outcome in diffuse large B-cell lymphoma

被引:27
作者
Eertink, J. J. [1 ,2 ,18 ]
Zwezerijnen, G. J. C. [2 ,3 ]
Heymans, M. W. [4 ,5 ]
Pieplenbosch, S. [2 ,3 ]
Wiegers, S. E. [2 ,3 ]
Duehrsen, U. [6 ]
Huttmann, A. [6 ]
Kurch, L. [7 ]
Hanoun, C. [6 ]
Lugtenburg, P. J. [8 ]
Barrington, S. F. [9 ,10 ]
Mikhaeel, N. G. [11 ,12 ]
Ceriani, L. [13 ,14 ,15 ]
Zucca, E. [15 ,16 ]
Czibor, S. [17 ]
Gyorke, T. [17 ]
Chamuleau, M. E. D. [1 ,2 ]
Hoekstra, O. S. [2 ,3 ]
de Vet, H. C. W. [4 ,5 ]
Boellaard, R. [2 ,3 ]
Zijlstra, J. M. [1 ,2 ]
机构
[1] Vrije Univ Amsterdam, Amsterdam Univ Med Ctr, Hematol, Amsterdam, Netherlands
[2] Canc Ctr Amsterdam, Imaging & Biomarkers, Amsterdam, Netherlands
[3] Vrije Univ Amsterdam, Amsterdam Univ Med Ctr, Radiol & Nucl Med, Amsterdam, Netherlands
[4] Locat Vrije Univ Amsterdam, Epidemiol & Data Sci, Amsterdam UMC, Amsterdam, Netherlands
[5] Amsterdam Publ Hlth Res Inst, Methodol, Amsterdam, Netherlands
[6] Univ Duisburg Essen, Univ Hosp Essen, West German Canc Ctr, Dept Hematol, Essen, Germany
[7] Univ Klinikum Leipzig, Klinik & Poliklin Nukl Med, Leipzig, Germany
[8] Erasmus MC Canc Inst, Univ Med Ctr Rotterdam, Dept Hematol, Rotterdam, Netherlands
[9] Kings Coll London, London, England
[10] Kings Coll London, Guys & St Thomas PET Ctr, Sch Biomed Engn & Imaging Sci, Kings Hlth Partners, London, England
[11] Kings Coll London Univ, Guys Canc Ctr, Dept Clin Oncol, London, England
[12] Kings Coll London Univ, Sch Canc & Pharmaceut Sci, London, England
[13] Univ Svizzera Italiana, Imaging Inst Southern Switzerland, Dept Nucl Med, Bellinzona, Switzerland
[14] Univ Svizzera Italiana, Imaging Inst Southern Switzerland, PET CT Ctr, Bellinzona, Switzerland
[15] SAKK Swiss Grp Clin Canc Res, Bern, Switzerland
[16] Univ Svizzera Italiana, IOSI Oncol Inst Southern Switzerland, Dept Oncol, Bellinzona, Switzerland
[17] Semmelweis Univ, Med Imaging Ctr, Dept Nucl Med, Budapest, Hungary
[18] Amsterdam UMC, Dept Hematol, Locat VUmc, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands
基金
英国工程与自然科学研究理事会;
关键词
METABOLIC TUMOR VOLUME; POSITRON-EMISSION-TOMOGRAPHY; INTERIM PET; SEGMENTATION; MULTICENTER; PROGRESSION; FEATURES; CRITERIA; BURDEN; MODELS;
D O I
10.1182/blood.2022018558
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The objective of this study is to externally validate the clinical positron emission tomography (PET) model developed in the HOVON-84 trial and to compare the model performance of our clinical PET model using the international prognostic index (IPI). In total, 1195 patients with diffuse large B-cell lymphoma (DLBCL) were included in the study. Data of 887 patients from 6 studies were used as external validation data sets. The primary outcomes were 2-year progression-free survival (PFS) and 2-year time to progression (TTP). The metabolic tumor volume (MTV), maximum distance between the largest lesion and another lesion (Dmaxbulk), and peak standardized uptake value (SUVpeak) were extracted. The predictive values of the IPI and clinical PET model (MTV, Dmaxbulk, SUVpeak, performance status, and age) were tested. Model performance was assessed using the area under the curve (AUC), and diagnostic performance, using the positive predictive value (PPV). The IPI yielded an AUC of 0.62. The clinical PET model yielded a significantly higher AUC of 0.71 (P < .001). Patients with high-risk IPI had a 2-year PFS of 61.4% vs 51.9% for those with high-risk clinical PET, with an increase in PPV from 35.5% to 49.1%, respectively. A total of 66.4% of patients with high-risk IPI were free from progression or relapse vs 55.5% of patients with high-risk clinical PET scores, with an increased PPV from 33.7% to 44.6%, respectively. The clinical PET model remained predictive of outcome in 6 independent first-line DLBCL studies, and had higher model performance than the currently used IPI in all studies.
引用
收藏
页码:3055 / 3064
页数:10
相关论文
共 49 条
  • [1] Baseline 18F-FDG PET radiomic features as predictors of 2-year event-free survival in diffuse large B cell lymphomas treated with immunochemotherapy
    Aide, Nicolas
    Fruchart, Christophe
    Nganoa, Catherine
    Gac, Anne-Claire
    Lasnon, Charline
    [J]. EUROPEAN RADIOLOGY, 2020, 30 (08) : 4623 - 4632
  • [2] EANM/EARL harmonization strategies in PET quantification: from daily practice to multicentre oncological studies
    Aide, Nicolas
    Lasnon, Charline
    Veit-Haibach, Patrick
    Sera, Terez
    Sattler, Bernhard
    Boellaard, Ronald
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2017, 44 : S17 - S31
  • [3] Automated Segmentation of Baseline Metabolic Total Tumor Burden in Diffuse Large B-Cell Lymphoma: Which Method Is Most Successful? A Study on Behalf of the PETRA Consortium
    Barrington, Sally F.
    Zwezerijnen, Ben G. J. C.
    de Vet, Henrica C. W.
    Heymans, Martijn W.
    Mikhaeel, N. George
    Burggraaff, Coreline N.
    Eertink, Jakoba J.
    Pike, Lucy C.
    Hoekstra, Otto S.
    Zijlstra, Jose M.
    Boellaard, Ronald
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2021, 62 (03) : 332 - 337
  • [4] Boellaard R, 2018, J NUCL MED, V59
  • [5] FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0
    Boellaard, Ronald
    Delgado-Bolton, Roberto
    Oyen, Wim J. G.
    Giammarile, Francesco
    Tatsch, Klaus
    Eschner, Wolfgang
    Verzijlbergen, Fred J.
    Barrington, Sally F.
    Pike, Lucy C.
    Weber, Wolfgang A.
    Stroobants, Sigrid
    Delbeke, Dominique
    Donohoe, Kevin J.
    Holbrook, Scott
    Graham, Michael M.
    Testanera, Giorgio
    Hoekstra, Otto S.
    Zijlstra, Josee
    Visser, Eric
    Hoekstra, Corneline J.
    Pruim, Jan
    Willemsen, Antoon
    Arends, Bertjan
    Kotzerke, Joerg
    Bockisch, Andreas
    Beyer, Thomas
    Chiti, Arturo
    Krause, Bernd J.
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2015, 42 (02) : 328 - 354
  • [6] Prospective International Cohort Study Demonstrates Inability of Interim PET to Predict Treatment Failure in Diffuse Large B-Cell Lymphoma
    Carr, Robert
    Fanti, Stefano
    Paez, Diana
    Cerci, Juliano
    Gyoerke, Tamas
    Redondo, Francisca
    Morris, Tim P.
    Meneghetti, Claudio
    Auewarakul, Chirayu
    Nair, Reena
    Gorospe, Charity
    Chung, June-Key
    Kuzu, Isinsu
    Celli, Monica
    Gujral, Sumeet
    Padua, Rose Ann
    Dondi, Maurizio
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2014, 55 (12) : 1936 - 1944
  • [7] Generation and validation of a PET radiomics model that predicts survival in diffuse large B cell lymphoma treated with R-CHOP14: A SAKK 38/07 trial post-hoc analysis
    Ceriani, Luca
    Milan, Lisa
    Cascione, Luciano
    Gritti, Giuseppe
    Dalmasso, Federico
    Esposito, Fabiana
    Pirosa, Maria Cristina
    Schaer, Saemi
    Bruno, Andrea
    Dirnhofer, Stephan
    Giovanella, Luca
    Hayoz, Stefanie
    Mamot, Christoph
    Rambaldi, Alessandro
    Chauvie, Stephane
    Zucca, Emanuele
    [J]. HEMATOLOGICAL ONCOLOGY, 2022, 40 (01) : 11 - 21
  • [8] Treatment of patients with MYC rearrangement positive large B-cell lymphoma with R-CHOP plus lenalidomide: results of a multicenter phase II HOVON trial
    Chamuleau, Martine E. D.
    Burggraaff, Coreline N.
    Nijland, Marcel
    Bakunina, Katerina
    Mous, Rogier
    Lugtenburg, Pieternella J.
    Dierickx, Daan
    van Imhoff, Gustaaf W.
    Vermaat, Joost S. P.
    Marijt, Eric A. F.
    Visser, Otto
    Mandigers, Caroline
    Bilgin, Yavuz M.
    Beeker, Aart
    Durian, Mark F.
    van Rees, Bas P.
    Bohmer, Lara H.
    Tick, Lidwine W.
    Boersma, Rinske S.
    Snijders, Tjeerd J. F.
    Schouten, Harry C.
    Koene, Harry R.
    de Jongh, Eva
    Hijmering, Nathalie
    Diepstra, Arjan
    van de Berg, Anke
    Arens, Anne I. J.
    Huijbregts, Julia
    Hoekstra, Otto
    Zijlstra, Josee M.
    de Jong, Daphne
    Kersten, Marie Jose
    [J]. HAEMATOLOGICA, 2020, 105 (12) : 2805 - 2812
  • [9] Risk stratification in diffuse large B-cell lymphoma using lesion dissemination and metabolic tumor burden calculated from baseline PET/CT
    Cottereau, A-S
    Meignan, M.
    Nioche, C.
    Capobianco, N.
    Clerc, J.
    Chartier, L.
    Vercellino, L.
    Casasnovas, O.
    Thieblemont, C.
    Buvat, I
    [J]. ANNALS OF ONCOLOGY, 2021, 32 (03) : 404 - 411
  • [10] 18F-FDG PET Dissemination Features in Diffuse Large B-Cell Lymphoma Are Predictive of Outcome
    Cottereau, Anne-Segolene
    Nioche, Christophe
    Dirand, Anne-Sophie
    Clerc, Jerome
    Morschhauser, Franck
    Casasnovas, Olivier
    Meignan, Michel
    Buvat, Irene
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2020, 61 (01) : 40 - 45